Recombinant humaan CD30/TNFRSF8-eiwit

TNFRSF8, also known as tumor necrosis factor receptor superfamily member 8, is a cell membrane protein of the tumor necrosis factor receptor superfamily and is expressed by activated T and B cells but not resting. It contributes to thymic negative selection by inducing the apoptotic cell death of CD4+CD8+ T cells. It can regulate proliferation of lymphocytes and may also play an important role in human immunodeficiency virus replication. Recombinant human TNFRSF8, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Human CD30 Ligand/TNFSF8 (CAT# ATGP3343) is coated at 2 µg/mL (100 ul/well) can bind Human CD30/TNFRSF8. The ED50 range ≤ 100 ng/mL.

Tumor necrosis factor receptor superfamily member 8, CD30L receptor, Ki-1 antigen, Lymphocyte activation antigen CD30, D1S166E

Baculovirus

Human

HIgG-His-Tag

SDS-PAGE, Bioactivity

0.5 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 85% by SDS-PAGE

Measured by its binding ability in a functional ELISA with Human CD30 Ligand/TNFSF8 (CAT# ATGP3343) . The ED50 range ≤ 100 ng/mL.

66.7 kDa (613aa)

CD30, TNFRSF8, Tumor necrosis factor receptor superfamily member 8, TNFRSF8, CD30, D1S166E, Ki-1, CD 30, CD30 antigen, CD30L receptor, Cytokine receptor CD30, D1S166E, KI 1, KI 1 antigen, Ki-1 antigen, KI1, Lymphocyte activation antigen CD30, TNFRSF 8, Tnfrsf8, TNR8_HUMAN, Tumor necrosis factor receptor superfamily member 8, ATGP3389-10 µg, ATGP3389-20 µg, ATGP3389-50 µg, ATGP3389-100 µg, ATGP3389-250 µg, ATGP3389-500 µg, ATGP3389-1 mg, ATGP3389-10, ATGP3389-20, ATGP3389-50, ATGP3389-100, ATGP3389-250, ATGP3389-500, ATGP3389-1

Kennedy MK., et al. (2006) Immunology 118:143-152.; ; Shanebeck SD., et al. (1995) Eur J Immunol. 25:2147-2153.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Immunology

NP_001234

P28908

Human

Ala

FPQDRPF EDTCHGNPSH YYDKAVRRCC YRCPMGLFPT QQCPQRPTDC RKQCEPDYYL DEADRCTACV TCSRDDLVEK TPCAWNSSRV CECRPGMFCS TSAVNSCARC FFHSVCPAGM IVKFPGTAQK NTVCEPASPG VSPACASPEN CKEPSSGTIP QAKPTPVSPA TSSASTMPVR GGTRLAQEAA SKLTRAPDSP SSVGRPSSDP GLSPTQPCPE GSGDCRKQCE PDYYLDEAGR CTACVSCSRD DLVEKTPCAW NSSRTCECRP GMICATSATN SCARCVPYPI CAAETVTKPQ DMAEKDTTFE APPLGTQPDC NPTPENGEAP ASTSPTQSLL VDSQASKTLP IPTSAPVALS STGK