Recombinant humaan CD320/TCblR/8D6A-eiwit

CD320, also known as CD320 antigen isoform 1, belongs to the low-density lipoprotein receptor family, with 2 low-density lipoprotein receptor type A domains separated by a complement-like cysteine-rich region. It binds TC- cobalamin (Cbl) and internalizes the complex by endocytosis. It is known to enhance proliferation of germinal center (GC) B cells and follicular dendritic cells. It augments the proliferation of PC precursors generated by IL-10. It collaborates with CD44 in supporting lymphomagenesis by a Burkitt lymphoma cell line, L3055. Recombinant human CD320, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

CD320 antigen isoform 1, CD320, 8D6, 8D6A, TCBLR

Baculovirus

Human

HIgG-His-Tag

SDS-PAGE

0.5 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 90% by SDS-PAGE

47.4 kDa (438aa)

CD320, TCblRD6A, CD320 antigen isoform 1, CD320, 8D6, 8D6A, TCBLR, ATGP3595-10 µg, ATGP3595-20 µg, ATGP3595-50 µg, ATGP3595-100 µg, ATGP3595-250 µg, ATGP3595-500 µg, ATGP3595-1 mg, ATGP3595-10, ATGP3595-20, ATGP3595-50, ATGP3595-100, ATGP3595-250, ATGP3595-500, ATGP3595-1

Quadros EV., et al. (2009) Blood. 113:186-192.; ; Zhang X., et al. (2001) J Immunol. 167:49-56.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Immunology

NP_057663

Q9NPF0

Human

Leu31