Recombinant humaan CD44 eiwit

CD44, also known as CD44 antigen isoform 1, is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. The most extensively characterized ligand for CD44 is hyaluronan, a component of the extracellular matrix. It is expressed on the majority of immune cells. The binding of CD44 to hyaluronan is induced on T lymphocytes after activation by antigen and on monocytes after stimulation by inflammatory agents. It improves the prognostic efficacy of tumor differentiation. It might be determinant of differentiation characteristics, imparting properties of increased self-renewal, migration, and invasion. Also it involved in lymphocyte activation, recirculation and homing, and hematopoiesis. Recombinant human CD44, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

CD44 antigen, CDw44, Epican, Extracellular matrix receptor III, ECMR-III, GP90 lymphocyte homing/adhesion receptor, HUTCH-I, Heparan sulfate proteoglycan, Hermes antigen, Hyaluronate receptor, Phagocytic glycoprotein 1, PGP-1, Phagocytic glycoprotein I, PGP-I, LHR, MDU2, MDU3, MIC4

Baculovirus

Human

HIgG-His-Tag

SDS-PAGE

0.25 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 95% by SDS-PAGE

49 kDa (439aa)

CD44, CD44 antigen isoform 1, CD44, CDW44, CSPG8, ECMR-III, HCELL, HUTCH-I, IN, LHR, MC56, MDU2, MDU3, MIC4, Pgp1, ATGP3785-10 µg, ATGP3785-20 µg, ATGP3785-50 µg, ATGP3785-100 µg, ATGP3785-250 µg, ATGP3785-500 µg, ATGP3785-1 mg, ATGP3785-10, ATGP3785-20, ATGP3785-50, ATGP3785-100, ATGP3785-250, ATGP3785-500, ATGP3785-1

Jackson DG., et al. (1992) Biol Chem. 267:4732-4739.; ; Morine Y., et al. (2017) Anticancer Res. 37:5701-5705.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Immunology

NP_000601

P16070

Human

Gln21

QIDLNITCRF AGVFHVEKNG RYSISRTEAA DLCKAFNSTL PTMAQMEKAL SIGFETCRYG FIEGHVVIPR IHPNSICAAN NTGVYILTSN TSQYDTYCFN ASAPPEEDCT SVTDLPNAFD GPITITIVNR DGTRYVQKGE YRTNPEDIYP SNPTDDDVSS GSSSERSSTS GGYIFYTFST VHPIPDEDSP WITDSTDRIP LEPKSCDKTH TCPPCPAPEL LGGPSVFLFP PKPKDTLMIS RTPEVTCVVV DVSHEDPEVK FNWYVDGVEV HNAKTKPREE QYNSTYRVVS VLTVLHQDWL NGKEYKCKVS NKALPAPIEK TISKAKGQPR EPQVYTLPPS RDELTKNQVS LTCLVKGFYP SDIAVEWESN GQPENNYKTT PPVLDSDGSF FLYSKLTVDK SRWQQGNVFS CSVMHEALHN HYTQKSLSLS PGKHHHHHH