Recombinant humaan CD46-eiwit

CD46, also known as membrane cofactor protein isoform 14, is a type 1 membrane protein that plays an important inhibitory role in the complement system. It is expressed in white blood cells, platelets, epithelial cells, and fibroblasts. The importance of CD46 to complement regulation is underscored by the observation that genetic loss of CD46 leads to development of atypical hemolytic-uremic syndrome, a disease characterized by uncontrolled complement activation. Recombinant human CD46, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Membrane cofactor protein isoform 14, CD46, AHUS2, MCP, MIC10, TLX, TRA2.10

Baculovirus

Human

His-Tag

SDS-PAGE

0.5 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 90% by SDS-PAGE

32.5 kDa (288aa)

CD46, Membrane cofactor protein isoform 14, CD46, AHUS2, MCP, MIC10, TLX, TRA2.10, ATGP3451-10 µg, ATGP3451-20 µg, ATGP3451-50 µg, ATGP3451-100 µg, ATGP3451-250 µg, ATGP3451-500 µg, ATGP3451-1 mg, ATGP3451-10, ATGP3451-20, ATGP3451-50, ATGP3451-100, ATGP3451-250, ATGP3451-500, ATGP3451-1

Lublin DM., et al. (1988) J Exp Med. 168:181-194.; ; Maga TK., et al. (2010) Hum. Mutat. 31:E1445-14460.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Immunology

NP_758860

P15529

Human

Ala

ADLCEEPPTF EAMELIGKPK PYYEIGERVD YKCKKGYFYI PPLATHTICD RNHTWLPVSD DACYRETCPY IRDPLNGQAV PANGTYEFGY QMHFICNEGY YLIGEEILYC ELKGSVAIWS GKPPICEKVL CTPPPKIKNG KHTFSEVEVF EYLDAVTYSC DPAPGPDPFS LIGESTIYCG DNSVWSRAAP ECKVVKCRFP VVENGKQISG FGKKFYYKAT VMFECDKGFY LDGSDTIVCD SNSTWDPPVP KCLKGPRPTY KPPVSNYPGY PKPEEGILDS LDHHHHHH