Recombinant humaan CD5-eiwit

CD5 is a good immunohistochemical marker for T-cells, although not as sensitive as CD3. About 76% of T-cell neoplasms are reported to express CD5, and it is also found in chronic lymphocytic leukemia, hairy cell leukemia, and mantle cell lymphoma cells. It is commonly lost in cutaneous T-cell lymphoma, and its absence can be used as an indicator of malignancy in this condition. The absence of CD5 in T cell acute lymphoblastic leukemia, while relatively rare, is associated with a poor prognosis. Recombinant human CD5 protein, fused to His-tag at N-terminus, was expressed in E. coli.

T-cell surface glycoprotein CD5, LEu1, T1

E.coli

Human

His-Tag

SDS-PAGE, Denatured

1 mg/mL (determined by Bradford assay)

> 80% by SDS-PAGE

41.0 kDa (371aa)

CD5, T-cell surface glycoprotein CD5, LEu1, T1, ATGP2639-10 µg, ATGP2639-20 µg, ATGP2639-50 µg, ATGP2639-100 µg, ATGP2639-250 µg, ATGP2639-500 µg, ATGP2639-1 mg, ATGP2639-10, ATGP2639-20, ATGP2639-50, ATGP2639-100, ATGP2639-250, ATGP2639-500, ATGP2639-1

Berland R. et al. (2002) Annu. Rev. Immunol. 20:253-300.; ; Osman N. et al. (1992) Eur. J. Immunol. 22:2995-3000.;

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol 0.4M urea

Immunology

NP_055022

P06127

Human

MGSSHHHHHH SSGLVPRGSH MGSRLSWYDP DFQARLTRSN SKCQGQLEVY LKDGWHMVCS QSWGRSSKQW EDPSQASKVC QRLNCGVPLS LGPFLVTYTP QSSIICYGQL GSFSNCSHSR NDMCHSLGLT CLEPQKTTPP TTRPPPTTTP EPTAPPRLQL VAQSGGQHCA GVVEFYSGSL GGTISYEAQD KTQDLENFLC NNLQCGSFLK HLPETEAGRA QDPGEPREHQ PLPIQWKIQN SSCTSLEHCF RKIKPQKSGR VLALLCSGFQ PKVQSRLVGG SSICEGTVEV RQGAQWAALC DSSSARSSLR WEEVCREQQC GSVNSYRVLD AGDPTSRGLF CPHQKLSQCH ELWERNSYCK KVFVTCQDPN P