Recombinant humaan CD52-eiwit

CD52, also known as CAMPATH-1 antigen, is a small glycosylphosphatidylinositol (GPI) anchored glycoprotein that is tethered to the cell surface with a GPI linkage. This protein can be targeted to induce immune suppression by complement-meditated cell lysis. CD52 is expressed on lymphocytes, monocytes, monocytes-derived dendritic cells, eosinophils, and neutrophils, but not on the stem cells from which these lymphocytes were derived. Also, it is an important target for therapeutic interventions aimed at leukocyte depletion in hematological malignancies and post-transplant immunosuppression. Recombinant human CD52, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

CAMPATH-1 antigen, CD52, CDW52, EDDM5

Baculovirus

Human

HIgG-His-Tag

SDS-PAGE

0.5 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 95% by SDS-PAGE

28.2 kDa (251aa)

CD52, CAMPATH-1 antigen, CD52, CDW52, EDDM5, ATGP3748-10 µg, ATGP3748-20 µg, ATGP3748-50 µg, ATGP3748-100 µg, ATGP3748-250 µg, ATGP3748-500 µg, ATGP3748-1 mg, ATGP3748-10, ATGP3748-20, ATGP3748-50, ATGP3748-100, ATGP3748-250, ATGP3748-500, ATGP3748-1

Xia MQ., et al, (1991) Eur. J. Immunol. 21:1677-1684.; ; Rowan WC., et al, (1995) Int. Immunol. 7:69-77.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Immunology

NP_001794

P31358

Human

Gly25

GQNDTSQTSS PSLEPKSCDK THTCPPCPAP ELLGGPSVFL FPPKPKDTLM ISRTPEVTCV VVDVSHEDPE VKFNWYVDGV EVHNAKTKPR EEQYNSTYRV VSVLTVLHQD WLNGKEYKCK VSNKALPAPI EKTISKAKGQ PREPQVYTLP PSRDELTKNQ VSLTCLVKGF YPSDIAVEWE SNGQPENNYK TTPPVLDSDG SFFLYSKLTV DKSRWQQGNV FSCSVMHEAL HNHYTQKSLS LSPGKHHHHH H