Recombinant humaan CD58/LFA-3 eiwit

CD58, also known as lymphocyte function-associated antigen 3 isoform 1, is a cell adhesion molecule expressed on Antigen Presenting Cells (APC), particularly macrophages. It binds to CD2 (LFA-2) on T cells and is important in strengthening the adhesion between the T cells and Professional Antigen Presenting Cells. It is an important regulator of immune cell function which occurs as both surface-associated and soluble forms. It is associated with increased risk for multiple sclerosis. Recombinant human CD58, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Lymphocyte function-associated antigen 3 isoform 1, CD58, ag3, LFA-3, LFA3

Baculovirus

Human

His-Tag

SDS-PAGE

1 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 95% by SDS-PAGE

22.5 kDa (196aa)

CD58, LFA3, Lymphocyte function-associated antigen 3 isoform 1, CD58, ag3, LFA-3, LFA3, ATGP3693-10 µg, ATGP3693-20 µg, ATGP3693-50 µg, ATGP3693-100 µg, ATGP3693-250 µg, ATGP3693-500 µg, ATGP3693-1 mg, ATGP3693-10, ATGP3693-20, ATGP3693-50, ATGP3693-100, ATGP3693-250, ATGP3693-500, ATGP3693-1

Abdul Razak FR., et al. (2016) Genes Immun. 17:363-366.; ; Kirby AC., et al. (2000) Cell Adhes Commun. 7:453-464.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Immunology

NP_001770

P19256

Human

Ala

ADPFSQQIYG VVYGNVTFHV PSNVPLKEVL WKKQKDKVAE LENSEFRAFS SFKNRVYLDT VSGSLTIYNL TSSDEDEYEM ESPNITDTMK FFLYVLESLP SPTLTCALTN GSIEVQCMIP EHYNSHRGLI MYSWDCPMEQ CKRNSTSIYF KMENDLPQKI QCTLSNPLFN TTSSIILTTC IPSSGHSRHR HHHHHH