Recombinant humaan CD66b/CEACAM8-eiwit

CEACAM-8, also known as CD66b, is a cell surface glycoprotein that plays a role in cell adhesion in a calcium-independent manner. It mediates heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6. Its main function is cell adhesion, cell migration, and pathogen binding. However, its biological functions are largely unknown in eosinophils. It has been reported that CEACAM-8 is highly expressed on the surface of human peripheral blood eosinophils isolated from healthy individuals and used as granulocyte marker. Recombinant human CEACAM-8, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Carcinoembryonic antigen-related cell adhesion molecule 8, CD67 antigen, Carcinoembryonic antigen CGM6, Non-specific cross-reacting antigen NCA-95, CD66b, CGM6, CD67, NCA-95, CEACAM8, CEA cell adhesion molecule 8

Baculovirus

Human

His-Tag

SDS-PAGE

1 mg/mL (determined by Absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 95% by SDS - PAGE

32.3kDa (292aa)

Carcinoembryonic antigen-related cell adhesion molecule 8, CD67 antigen, Carcinoembryonic antigen CGM6, Non-specific cross-reacting antigen NCA-95, CD66b, CGM6, CD67, NCA-95, ATGP4004-10 µg, ATGP4004-50 µg, ATGP4004-100 µg, ATGP4004-200ug, ATGP4004-250 µg, ATGP4004-500 µg, ATGP4004-1 mg, ATGP4004-10 µg, ATGP4004-20 µg, ATGP4004-50 µg, ATGP4004-100 µg, ATGP4004-250 µg, ATGP4004-500 µg, ATGP4004-1 mg, ATGP4004-10, ATGP4004-20, ATGP4004-50, ATGP4004-100, ATGP4004-250, ATGP4004-500, ATGP4004-1

Kuroki M., et al, (2001) J Leukoc Biol. 70:543-550.; ; Ilie M., et al, (2012) Cancer. 118:1726-1737.; ; Posabella A, et al, (2020) J Cancer Res Clin Oncol. 146:127-136.;

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid. In Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Immunology

NP_001807

P31997

Human

Gln 35