Recombinant humaan CD8 bèta-eiwit

CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 beta chain isoforms. Recombinant human CD8B protein, fused to His-tag at N-terminus, was expressed in E. coli.

T-cell surface glycoprotein CD8 beta chain isoform 5 precursor, CD8B1, LEu2, LY3, LYT3, P37

E.coli

Human

His-Tag

SDS-PAGE, Denatured

0.5 mg/mL (determined by Bradford assay)

> 85% by SDS-PAGE

19.2 kDa (172aa)

CD8 b, ATGP2520-10 µg, ATGP2520-20 µg, ATGP2520-50 µg, ATGP2520-100 µg, ATGP2520-250 µg, ATGP2520-500 µg, ATGP2520-1 mg, ATGP2520-10, ATGP2520-20, ATGP2520-50, ATGP2520-100, ATGP2520-250, ATGP2520-500, ATGP2520-1

Heigele, A, et al. (2012) J. Virol. 86 (1), 36-48; ; Laugel, B., et al. (2011) J. Leukoc. Biol. 90 (6), 1089-1099;

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing, 0.4M Urea, 10% glycerol

Immunology

NP_004922

P10966

Human

LQQTPAY IKVQTNKMVM LSCEAKISLS NMRIYWLRQR QAPSSDSHHE FLALWDSAKG TIHGEEVEQE KIAVFRDASR FILNLTSVKP EDSGIYFCMI VGSPELTFGK GTQLSVVDFL PTTAQPTKKS TLKKRVCRLP RPETQKGPLC SP