Recombinant humaan CD89/FCAR-eiwit

FCAR, also known as immunoglobulin alpha Fc receptor isoform, is a member of the multichain immune recognition receptor family which is the most abundant immunoglobulin in mucosal areas but is only the second most common antibody isotype in serum. It plays a role in both pro- and anti-inflammatory responses depending on the state of IgA bound. It is also an important Fc receptor for neutrophil killing of tumor cells. When FCAR expressing neutrophils come into contact with IgA-opsonized tumor cells, the neutrophils not only perform antibody-dependent cell-mediated cytotoxicity, but also release the cytokines TNF-alpha and IL-1beta which cause increased neutrophil migration to the site. Recombinant human FCAR, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

CD89, CTB-61M7.2, Fc alpha receptor, Fc fragment of IgA receptor, FcalphaR, FcalphaRI, FCAR, IgA Fc receptor, Immunoglobulin alpha Fc receptor isoform

Baculovirus

Human

His-Tag

SDS-PAGE

0.25 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 85% by SDS-PAGE

24.5 kDa (215aa)

FCAR, CD89, Immunoglobulin alpha Fc receptor isoform, FCAR, CD89, CTB-61M7.2, FcalphaRI, ATGP3660-10 µg, ATGP3660-20 µg, ATGP3660-50 µg, ATGP3660-100 µg, ATGP3660-250 µg, ATGP3660-500 µg, ATGP3660-1 mg, ATGP3660-10, ATGP3660-20, ATGP3660-50, ATGP3660-100, ATGP3660-250, ATGP3660-500, ATGP3660-1

Maliszewski, C. R., et al. (1990) J. Exp. Med. 172:1665-1672.; ; Kanamaru, Y., et al. (2007) Blood. 109:203-211.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Immunology

NP_001991

P24071

Human

Ala

ADPQEGDFPM PFISAKSSPV IPLDGSVKIQ CQAIREAYLT QLMIIKNSTY REIGRRLKFW NETDPEFVID HMDANKAGRY QCQYRIGHYR FRYSDTLELV VTGLYGKPFL SADRGLVLMP GENISLTCSS AHIPFDRFSL AKEGELSLPQ HQSGEHPANF SLGPVDLNVS GIYRCYGWYN RSPYLWSFPS NALELVVTDS IHQDYTTQNH HHHHH