Recombinant humaan Chemerine-eiwit

Chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), is a distant member of the Cystatin superfamily. It is involved in multiple cancers, including adrenocortical carcinoma (ACC) . This protein in serum is transcriptionally downregulated in multiple cancer types. On the other hands, overexpression of this protein inhibits Wnt/beta-catenin pathway activity by promoting beta-catenin phosphorylation and degradation. Also, it has been implicated in autocrine/paracrine signaling for adipocyte differentiation and also stimulation of lipolysis. It was found to stimulate chemotaxis of dendritic cells and macrophages to the site of inflammation. Recombinant human Chemerin protein, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Retinoic acid receptor responder protein 2, RARRES2, HP10433, TIG2

HEK293

Human

His-Tag

SDS-PAGE

0.5 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 90% by SDS-PAGE

16.6 kDa (143aa)

Chemerin, ChemerinRetinoic acid receptor responder protein 2, RARRES2, HP10433, TIG2, ATGP3855-10 µg, ATGP3855-20 µg, ATGP3855-50 µg, ATGP3855-100 µg, ATGP3855-250 µg, ATGP3855-500 µg, ATGP3855-1 mg, ATGP3855-10, ATGP3855-20, ATGP3855-50, ATGP3855-100, ATGP3855-250, ATGP3855-500, ATGP3855-1

Reverchon M., et al, (2014) Biol Reprod. 90:102.; ; Liu-Chittenden Y., et al, (2016) J Clin Endocrinol Metab. 101 (9) :3345-3352.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Cardiovascular

NP_002880.1

Q99969

Human

Glu21