Recombinant humaan Chitinase 3-achtig 1/CHI3L1-eiwit

CHI3L1, also known as chitinase-3-like protein 1, is a member of the glycosyl hydrolase 18 family. This protein can bind heparins, probably as heparin sulfate. It has been found to enhance cell adhesion and promote cell signaling, proliferation and tumor angiogenesis. Elevated serum CHI3L1 levels occur in some conditions characterized by inflammation and connective tissue remodeling such as arthritis, chronic obstructive pulmonary disease, diabetes, cardiovascular disease, inflammatory bowel disease, and liver cirrhosis. Recombinant human CHI3L1, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques

Chitinase 3-like 1, cartilage glycoprotein-39, CGP-39; GP-39; hCGP-39, YKL40, YKL-40, YK-40, 39 kDa synovial protein, ASRT7

Baculovirus

Human

His-Tag

SDS-PAGE

0.25 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 90% by SDS-PAGE

41.4 kDa (370aa)

Chitinase3-like1, Chitinase-3-like protein 1 , CHI3L1, ASRT7, CGP-39, GP-39, GP39, HC-gp39, hCGP-39, HCGP-3P, YKL-40, YYL-40, 39 kDa synovial protein, ASRT7, Cartilage glycoprotein 39CGP-39, CGP39, CH3L1_HUMAN, CHI3L1, chitinasechitinase 3 like 1, chitinase 3 like 1 (cartilage glycoprotein 39), Chitinase 3 like protein 1 precursorChitinase-3-like protein 1, Chondrocyte protein YKL40GP 39, GP-39, GP39, HC gp39, HCGP 3P, hCGP-39HCgp39, YKL 40, YKL-40, YKL40, YYL 40, ATGP3405-10 µg, ATGP3405-20 µg, ATGP3405-50 µg, ATGP3405-100 µg, ATGP3405-250 µg, ATGP3405-500 µg, ATGP3405-1 mg, ATGP3405-10, ATGP3405-20, ATGP3405-50, ATGP3405-100, ATGP3405-250, ATGP3405-500, ATGP3405-1

Hakala BE., et al. (1993) J Biol Chem 268:25803-25810.; ; Eurich K., et al. (2009) World J Gastroenterol. 15:5249-5259.;

Suzuki H, et al. YKL-40 Promotes Proliferation of Cutaneous T-Cell Lymphoma Tumor Cells through Extracellular Signal-Regulated Kinase Pathways. (J Invest Dermatol. 2020) {https://pubmed.ncbi.nlm.nih.gov/31622598/}

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol, 1mM DTT

Signal Transduction

NP_001267

P36222

Human

Tyr22