Recombinant humaan Chondromomuline/LECT1-eiwit

LECT1 is a glycosylated transmembrane protein that is cleaved to form a mature, secreted protein. The N-terminus of the precursor protein shares characteristics with other surfactant proteins and is sometimes called chondrosurfactant protein although no biological activity has yet been defined for it. The C-terminus of the precursor protein contains a 25 kDa mature protein called leukocyte cell-derived chemotaxin-1 or chondromodulin-1. The mature protein promotes chondrocyte growth and inhibits angiogenesis. This gene is expressed in the avascular zone of prehypertrophic cartilage and its expression decreases during chondrocyte hypertrophy and vascular invasion. The mature protein likely plays a role in endochondral bone development by permitting cartilaginous anlagen to be vascularized and replaced by bone. It may be involved also in the broad control of tissue vascularization during development. Recombinant human LECT1 protein, fused to His-tag at N-terminus, was expressed in E. coli.

Leukocyte cell-derived chemotaxin 1 isoform 2, BRICD3, CHM-I, CHM1, MYETS1, CNMD, LECT1, Multiple myeloma tumor suppressor 1, BRICHOS domain containing 3

E.coli

Human

His-Tag

SDS-PAGE, Denatured

1 mg/mL (determined by Bradford assay)

> 90% by SDS-PAGE

16.3 kDa (144aa)

LECT1, leukocyte cell-derived chemotaxin 1 isoform 1, BRICD3, CHM-I, CHM1, MYETS1, ATGP2523-10 µg, ATGP2523-20 µg, ATGP2523-50 µg, ATGP2523-100 µg, ATGP2523-250 µg, ATGP2523-500 µg, ATGP2523-1 mg, ATGP2523-10, ATGP2523-20, ATGP2523-50, ATGP2523-100, ATGP2523-250, ATGP2523-500, ATGP2523-1

Fujii, M., et al. (2013) J. Orthop. Res. 31 (4), 538-543

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M uREA, 10% glycerol

Cancer

NP_008946

O75829

Human

MGSSHHHHHH SSGLVPRGSH MGSREVVRKI VPTTTKRPHS GPRSNPGAGR LNNETRPSVQ EDSQAFNPDN PYHQQEGESM TFDPRLDHEG ICCIECRRSY THCQKICEPL GGYYPWPYNY QGCRSACRVI MPCSWWVARI LGMV