Recombinant humaan CHRNA6-eiwit

Cholinergic receptor, nicotinic, alpha 6, also known as CHRNA6, belongs to the nicotinic acetylcholine receptors (nAChRs) family. nAChRs are heteropentameric ligand-gated ion channels resulting from the assembly of alpha and beta protein subunits. This ion channel is gated by the binding of acetylcholine to the assembled receptor. Alpha 6 is often found associated with beta 3, beta 2, and alpha 4 subunits. CHRNA6 receptors have a relatively selective localization to the nigrostriatal pathway where they function to mediate dopamine release. Recombinant human CHRNA6 protein, fused to His-tag at N-terminus, was expressed in E. coli.

Cholinergic receptor nicotinic alpha, Cholinergic receptor, nicotinic, alpha, CHNRA6

E.coli

Human

His-Tag

SDS-PAGE, Denatured

1 mg/mL (determined by Bradford assay)

> 85% by SDS-PAGE

29.3 kDa (250aa)

CHRNA6, Cholinergic receptor nicotinic alpha, Cholinergic receptor, nicotinic, alpha, CHNRA6, ATGP2572-10 µg, ATGP2572-20 µg, ATGP2572-50 µg, ATGP2572-100 µg, ATGP2572-250 µg, ATGP2572-500 µg, ATGP2572-1 mg, ATGP2572-10, ATGP2572-20, ATGP2572-50, ATGP2572-100, ATGP2572-250, ATGP2572-500, ATGP2572-1

Keskitalo Vuokko k., et al. (2011) Nicotine Tob Res. 13 (8) : 686-90.; ; Groot Kormrlink P J., et al. (2004) J Gen Physiol. 123: 697-708.;

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol

Neuroscience

NP_004189

Q15825

Human

MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSKGCV GCATEERLFH KLFSHYNQFI RPVENVSDPV TVHFEVAITQ LANVDEVNQI METNLWLRHI WNDYKLRWDP MEYDGIETLR VPADKIWKPD IVLYNNAVGD FQVEGKTKAL LKYNGMITWT PPAIFKSSCP MDITFFPFDH QNCSLKFGSW TYDKAEIDLL IIGSKVDMND FWENSEWEII DASGYKHDIK YNCCEEIYTD ITYSFYIRRL