Recombinant humaan COPS6-eiwit

COPS6 is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein belongs to translation initiation factor 3 (eIF3) superfamily. It is involved in the regulation of cell cycle and likely to be a cellular cofactor for HIV-1 accessory gene product Vpr. Recombinant human COPS6 protein, fused to His-tag at N-terminus, was expressed in E. coli.

COP9 signalosome complex subunit 6, CSN6, MOV34-34KD

E.coli

Human

His-Tag

SDS-PAGE, Denatured

0.25 mg/mL (determined by Bradford assay)

> 80% by SDS-PAGE

38.9 kDa (347aa)

COPS6, COP9 signalosome complex subunit 6, CSN6, MOV34-34KD, ATGP2261-10 µg, ATGP2261-20 µg, ATGP2261-50 µg, ATGP2261-100 µg, ATGP2261-250 µg, ATGP2261-500 µg, ATGP2261-1 mg, ATGP2261-10, ATGP2261-20, ATGP2261-50, ATGP2261-100, ATGP2261-250, ATGP2261-500, ATGP2261-1

Zhao, R., et al. (2011) J. Clin. Invest. 121 (3), 851-865; ; Sowa, M.E., et al. (2009) Cell 138 (2), 389-403

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M uREA, 10% glycerol

Epigenomics (Transcription & Translation)

NP_006824

Q7L5N1

Human

MGSSHHHHHH SSGLVPRGSH MAAAAAAAAA TNGTGGSSGM EVDAAVVPSV MACGVTGSVS VALHPLVILN ISDHWIRMRS QEGRPVQVIG ALIGKQEGRN IEVMNSFELL SHTVEEKIII DKEYYYTKEE QFKQVFKELE FLGWYTTGGP PDPSDIHVHK QVCEIIESPL FLKLNPMTKH TDLPVSVFES VIDIINGEAT MLFAELTYTL ATEEAERIGV DHVARMTATG SGENSTVAEH LIAQHSAIKM LHSRVKLILE YVKASEAGEV PFNHEILREA YALCHCLPVL STDKFKTDFY DQCNDVGLMA YLGTITKTCN TMNQFVNKFN VLYDRQGIGR RMRGLFF