Recombinant humaan CREG/CREG1-eiwit

CREG1 both activates and represses gene expression to promote cellular proliferation and inhibit differentiation. This protein antagonizes transcriptional activation and cellular transformation by E1A. It shares limited sequence similarity with E1A and binds both the general transcription factor TBP and the tumor suppressor pRb in vitro. CREG1 may contribute to the transcriptional control of cell growth and differentiation. Recombinant human CREG1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Cellular repressor of E1A-stimulated genes 1, CREG

E.coli

Human

His-Tag

SDS-PAGE

1 mg/mL (determined by Bradford assay)

> 95% by SDS-PAGE

23.6 kDa (213aa) confirmed by MALDI-TOF

CREG, Cellular repressor of E1A-stimulated genes 1, CREG, ATGP1689-10 µg, ATGP1689-20 µg, ATGP1689-50 µg, ATGP1689-100 µg, ATGP1689-250 µg, ATGP1689-500 µg, ATGP1689-1 mg, ATGP1689-10, ATGP1689-20, ATGP1689-50, ATGP1689-100, ATGP1689-250, ATGP1689-500, ATGP1689-1

Wang, N., et al. (2011) Atherosclerosis 218 (2), 543-551; ; Han, Y., et al. (2011) J. Mol. Cell. Cardiol. 50 (4), 723-730

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol

Cancer

NP_003842

O75629

Human

RGGRDH GDWDEASRLP PLPPREDAAR VARFVTHVSD WGALATISTL EAVRGRPFAD VLSLSDGPPG AGSGVPYFYL SPLQLSVSNL QENPYATLTM TLAQTNFCKK HGFDPQSPLC VHIMLSGTVT KVNETEMDIA KHSLFIRHPE MKTWPSSHNW FFAKLNITNI WVLDYFGGPK IVTPEEYYNV TVQ