Recombinant humaan CRHBP-eiwit

Corticotropin-releasing hormone is a potent stimulator of synthesis and secretion of preopiomelanocortin-derived peptides. Although CRH concentrations in the human peripheral circulation are normally low, they increase throughout pregnancy and fall rapidly after parturition. Maternal plasma CRH probably originates from the placenta. Human plasma contains a CRH-binding protein which inactivates CRH and which may prevent inappropriate pituitary-adrenal stimulation in pregnancy. Recombinant human CRHBP protein, fused to His-tag at N-terminus, was expressed in E. coli.

Corticotropin-releasing factor-binding protein precursor, corticotropin-releasing factor-binding protein precursor, CRF-BP, CRFBP

E.coli

Human

His-Tag

SDS-PAGE, Denatured

1 mg/mL (determined by Bradford assay)

> 85% by SDS-PAGE

36.1 kDa (324aa)

CRHBP, corticotropin-releasing factor-binding protein precursor, corticotropin-releasing factor-binding protein precursor, CRF-BP, CRFBP, ATGP2557-10 µg, ATGP2557-20 µg, ATGP2557-50 µg, ATGP2557-100 µg, ATGP2557-250 µg, ATGP2557-500 µg, ATGP2557-1 mg, ATGP2557-10, ATGP2557-20, ATGP2557-50, ATGP2557-100, ATGP2557-250, ATGP2557-500, ATGP2557-1

Behan DP. et al. (1993) Genomics. 16:63-68.; ; Westphal NJ. et al. (2006) Front. Biosc.. 11: 1878-91.;

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol 0.4M urea

Signal Transduction

NP_001873

P24387

Human

MGSSHHHHHH SSGLVPRGSH MGSESRYLEL REAADYDPFL LFSANLKREL AGEQPYRRAL RCLDMLSLQG QFTFTADRPQ LHCAAFFISE PEEFITIHYD QVSIDCQGGD FLKVFDGWIL KGEKFPSSQD HPLPSAERYI DFCESGLSRR SIRSSQNVAM IFFRVHEPGN GFTLTIKTDP NLFPCNVISQ TPNGKFTLVV PHQHRNCSFS IIYPVVIKIS DLTLGHVNGL QLKKSSAGCE GIGDFVELLG GTGLDPSKMT PLADLCYPFH GPAQMKVGCD NTVVRMVSSG KHVNRVTFEY RQLEPYELEN PNGNSIGEFC LSGL