Recombinant humaan CRLF2-eiwit

CRLF2 is a receptor for thymic stromal lymphopoietin (TSLP) . Together with the interleukin 7 receptor (IL7R), the protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Two transcript variants encoding different isoforms have been found for this gene. Recombinant human CRLF2 protein, fused to His-tag at N-terminus, was expressed in E. coli.

Cytokine receptor-like factor 2 isoform 1 precursor, CRL2, CRLF2Y, TSLPR, Cytokine receptor-like factor 2 isoform 1, CRLF2, Cytokine receptor-like 2, ILXR, Thymic stromal lymphopoietin protein receptor, TSLP receptor

E.coli

Human

His-Tag

SDS-PAGE, Denatured

1 mg/mL (determined by Bradford assay)

> 85% by SDS-PAGE

26.6 kDa (232aa)

TSLPR, TSLP R, Cytokine receptor-like factor 2 isoform 1 precursor, CRLF2Y, CRLF2, CRL2, ATGP2022-10 µg, ATGP2022-20 µg, ATGP2022-50 µg, ATGP2022-100 µg, ATGP2022-250 µg, ATGP2022-500 µg, ATGP2022-1 mg, ATGP2022-010, ATGP2022-020, ATGP2022-050, ATGP2022-100, ATGP2022-250, ATGP2022-500, ATGP2022-01M

Chen, I.M., et al. (2012) Blood 119 (15), 3512-3522; ; Haslam, K., et al. (2011) Int J Lab Hematol 33 (6), E17-E19;

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M uREA, 10% glycerol

Immunology

NP_071431

Q9HC73

Human

QGGAAEG VQIQIIYFNL ETVQVTWNAS KYSRTNLTFH YRFNGDEAYD QCTNYLLQEG HTSGCLLDAE QRDDILYFSI RNGTHPVFTA SRWMVYYLKP SSPKHVRFSW HQDAVTVTCS DLSYGDLLYE VQYRSPFDTE WQSKQENTCN VTIEGLDAEK CYSFWVRVKA MEDVYGPDTY PSDWSEVTCW QRGEIRDACA ETPTPPKPKL SK