Recombinant humaan CRTAM-eiwit

CRTAM, also known as cytotoxic and regulatory T-cell molecule, is a member of the immunoglobulin superfamily that complies with the structural characteristics of the JAM family of proteins and is phylogenetically more closely related to nectin-like proteins. It is a molecule involved in epithelial cell adhesion. This protein interacts with CADM1 promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. Recombinant human CRTAM, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

CRTAM, CD355

Baculovirus

Human

His-Tag

SDS-PAGE

1 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 90% by SDS-PAGE

31kDa (278aa)

CRTAM, CRTAM, CD355, ATGP3216-10 µg, ATGP3216-20 µg, ATGP3216-50 µg, ATGP3216-100 µg, ATGP3216-250 µg, ATGP3216-500 µg, ATGP3216-1 mg, ATGP3216-10, ATGP3216-20, ATGP3216-50, ATGP3216-100, ATGP3216-250, ATGP3216-500, ATGP3216-1

Kennedy J., et al. (2000) J. Leukoc. Biol. 67:725-734.; ; Boles K.S., et al. (2005) Blood 106:779-786.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Immunology

NP_062550

O95727

Human

SLTNHTETIT VEEGQTLTLK CVTSLRKNSS LQWLTPSGFT IFLNEYPALK NSKYQLLHHS ANQLSITVPN VTLQDEGVYK CLHYSDSVST KEVKVIVLAT PFKPILEASV IRKQNGEEHV VLMCSTMRSK PPPQITWLLG NSMEVSGGTL HEFETDGKKC NTTSTLIIHT YGKNSTVDCI IRHRGLQGRK LVAPFRFEDL VTDEETASDA LERNSLSSQD PQQPTSTVSV TEDSSTSEID KEEKEQTTQD PDLTTEANPQ YLGLARKKSG LEHHHHHH