Recombinant humaan CRTAP-eiwit

Cartilage-associated protein precursor, also known as CRTAP, is a secreted protein localizing to the extracellular space that plays a role in collagen post-translational modifications, extracellular fibril assembly and intracellular trafficking. CRTAP is widely expressed with predominant expression in articular chondrocytes. Mutations in the gene encoding CRTAP can lead to autosomal recessive osteogenesis imperfecta (OI) type 7 and type 2B. OI, also known as brittle bone disease, is characterized by bone fragility and susceptibility to fractures. Recombinant human CRTAP protein, fused to His-tag at N-terminus, was expressed in E. coli.

Cartilage-associated protein precursor, Cartilage-associated protein precursor, CASP, LEPREL3, OI7

E.coli

Human

His-Tag

SDS-PAGE, Denatured

0.5 mg/mL (determined by Bradford assay)

> 85% by SDS-PAGE

46.4 kDa (398aa)

CRTAP, Cartilage-associated protein precursor, Cartilage-associated protein precursor, CASP, LEPREL3, OI7, ATGP2548-10 µg, ATGP2548-20 µg, ATGP2548-50 µg, ATGP2548-100 µg, ATGP2548-250 µg, ATGP2548-500 µg, ATGP2548-1 mg, ATGP2548-10, ATGP2548-20, ATGP2548-50, ATGP2548-100, ATGP2548-250, ATGP2548-500, ATGP2548-1

Tonachini L., et al. (1999) Cytogenet Cell Genet. 87: 191-194.; ; Castagnola P., et al. (1997) J Cell Sci. 110: 1351-1359.;

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol

Signal Transduction

NP_006362

O75718

Human

QYERYSF RSFPRDELMP LESAYRHALD KYSGEHWAES VGYLEISLRL HRLLRDSEAF CHRNCSAAPQ PEPAAGLASY PELRLFGGLL RRAHCLKRCK QGLPAFRQSQ PSREVLADFQ RREPYKFLQF AYFKANNLPK AIAAAHTFLL KHPDDEMMKR NMAYYKSLPG AEDYIKDLET KSYESLFIRA VRAYNGENWR TSITDMELAL PDFFKAFYEC LAACEGSREI KDFKDFYLSI ADHYVEVLEC KIQCEENLTP VIGGYPVEKF VATMYHYLQF AYYKLNDLKN AAPCAVSYLL FDQNDKVMQQ NLVYYQYHRD TWGLSDEHFQ PRPEAVQFFN VTTLQKELYD FAKENIMDDD EGEVVEYVDD LLELEETS