Recombinant humaan CSK-eiwit

CSK is a tyrosine-protein kinase CSK that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK.. Recombinant human CSK protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Tyrosine-protein kinase CSK, Tyrosine-protein kinase CSK, C-Src kinase, Protein-tyrosine kinase CYL, Tyrosine protein kinase CSK

E.coli

Human

His-Tag

SDS-PAGE

0.5 mg/mL (determined by Bradford assay)

> 95% by SDS-PAGE

53.1 kDa (473aa)

CSK, Tyrosine-protein kinase CSK, Tyrosine-protein kinase CSK, C-Src kinase, Protein-tyrosine kinase CYL, Tyrosine protein kinase CSK, ATGP2842-10 µg, ATGP2842-20 µg, ATGP2842-50 µg, ATGP2842-100 µg, ATGP2842-250 µg, ATGP2842-500 µg, ATGP2842-1 mg, ATGP2842-10, ATGP2842-20, ATGP2842-50, ATGP2842-100, ATGP2842-250, ATGP2842-500, ATGP2842-1

Braeuninger A., et al. (1991) Proc. Natl. Acad. Sci. u.S.A. 88:10411-10415

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 20% glycerol, 1mM DTT

Signal Transduction

NP_001120662.1

P41240

Human

MSAIQAA WPSGTECIAK YNFHGTAEQD LPFCKGDVLT IVAVTKDPNW YKAKNKVGRE GIIPANYVQK REGVKAGTKL SLMPWFHGKI TREQAERLLY PPETGLFLVR ESTNYPGDYT LCVSCDGKVE HYRIMYHASK LSIDEEVYFE NLMQLVEHYT SDADGLCTRL IKPKVMEGTV AAQDEFYRSG WALNMKELKL LQTIGKGEFG DVMLGDYRGN KVAVKCIKND ATAQAFLAEA SVMTQLRHSN LVQLLGVIVE EKGGLYIVTE YMAKGSLVDY LRSRGRSVLG GDCLLKFSLD VCEAMEYLEG NNFVHRDLAA RNVLVSEDNV AKVSDFGLTK EASSTQDTGK LPVKWTAPEA LREKKFSTKS DVWSFGILLW EIYSFGRVPY PRIPLKDVVP RVEKGYKMDA PDGCPPAVYE VMKNCWHLDA AMRPSFLQLR EQLEHIKTHE LHL