Recombinant humaan CTHRC1-eiwit

CTHRC1, also known as collagen triple helix repeat-containing protein 1 isoform 1, is a secreted glycoprotein that is expressed on renal epithelium, neurons, osteoblasts, and smooth muscle cells. This protein is overexpressed in different kinds of cancer tissues and promotes tumor formation. It acts as a negative regulator of collagen matrix deposition and is involved in cell migration, motility and invasion. The hormonal functions of CTHRC1 include regulation of lipid storage and cellular glycogen levels with potentially far-reaching implications for cell metabolism and physiology. Additionally, CTHRC1 increases bone mass as a positive regulator of osteoblastic bone formation and offers an anabolic approach for the treatment of osteoporosis. Recombinant human CTHRC1, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Collagen triple helix repeat-containing protein 1 isoform 1, CTHRC1, Protein NMTC1

Baculovirus

Human

His-Tag

SDS-PAGE

0.5 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 90% by SDS-PAGE

24.1 kDa (222aa)

CTHRC1, ATGP3863-10 µg, ATGP3863-20 µg, ATGP3863-50 µg, ATGP3863-100 µg, ATGP3863-250 µg, ATGP3863-500 µg, ATGP3863-1 mg, ATGP3863-10, ATGP3863-20, ATGP3863-50, ATGP3863-100, ATGP3863-250, ATGP3863-500, ATGP3863-1

Jin YR., et al. (2017) Bone. 97:153-167. ; ; He W., et al. (2018) BMC Cancer. 18:400. doi

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Cytoskeleton

NP_612464

Q96CG8

Human

Ala

SEIPKGK QKAQLRQREV VDLYNGMCLQ GPAGVPGRDG SPGANGIPGT PGIPGRDGFK GEKGECLRES FEESWTPNYK QCSWSSLNYG IDLGKIAECT FTKMRSNSAL RVLFSGSLRL KCRNACCQRW YFTFNGAECS GPLPIEAIIY LDQGSPEMNS TINIHRTSSV EGLCEGIGAG LVDVAIWVGT CSDYPKGDAS TGWNSVSRII IEELPK