Recombinant humaan CTLA-4 eiwit met C-terminaal humaan Fc-tag
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
Expression Host : HEK293 The protein has a predicted molecular mass of 39.6 kDa after removal of the signal peptide.The apparent molecular mass of CTLA4-hFC is approximately 40-55 kDa due to glycosylation. This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.
CTLA4, CD152
The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
Delivery in 1-2 weeks
Store at -80°C for 12 months (Avoid repeated freezing and thawing)
Beschrijving
Expression Host : HEK293 The protein has a predicted molecular mass of 39.6 kDa after removal of the signal peptide.The apparent molecular mass of CTLA4-hFC is
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