Recombinant humaan DAP10/HCST-eiwit

HCST, also known as hematopoietic cell signal transducer isoform 1, is a member of the DAP10 family. It can be part of an immunoreceptor complex. This receptor plays an important role in inducing cytotoxicity against MHC class I chain-associated MICA and target cells expressing cell surface ligands such as MICB and UL16-binding protein (ULBP) . This receptor complex can play a role in cell survival and proliferation by activation of NK and T cell responses. Recombinant human HCST, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Hematopoietic cell signal transducer isoform 1, HCST, DAP10, KAP10, PIK3AP

Baculovirus

Human

HIgG-His-Tag

SDS-PAGE

1 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 90% by SDS-PAGE

30.1 kDa (271aa)

DAP10, HCST, Hematopoietic cell signal transducer isoform 1, HCST, DAP10, KAP10, PIK3AP, ATGP3745-10 µg, ATGP3745-20 µg, ATGP3745-50 µg, ATGP3745-100 µg, ATGP3745-250 µg, ATGP3745-500 µg, ATGP3745-1 mg, ATGP3745-10, ATGP3745-20, ATGP3745-50, ATGP3745-100, ATGP3745-250, ATGP3745-500, ATGP3745-1

Karimi M., et al. (2006) J Immunol. 175:7819-7828.; ; Andre P., et al. (2004) Eur J Immunol. 34:961-971.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Signal Transduction

NP_055081

Q9UBK5

Human

Ala

TTPGERS SLPAFYPGTS GSCSGCGSLS LP