Recombinant humaan delta Sarcoglycan/SGCD-eiwit

SGCD is one of the four known components of the sarcoglycan complex, which is a subcomplex of the dystrophin-glycoprotein complex (DGC) . DGC forms a link between the F-actin cytoskeleton and the extracellular matrix. This protein is expressed most abundantly in skeletal and cardiac muscle. The mutations in this gene have been associated with autosomal recessive limb-girdle muscular dystrophy and dilated cardiomyopathy. Alternatively spliced transcript variants encoding distinct isoforms have been observed. In melanocytic cells SGCD gene expression may be regulated by MITF. Recombinant human SGCD protein, fused to His-tag at N-terminus, was expressed in E. coli.

Delta-sarcoglycan, 35DAG, CMD1L, DAGD, SG-delta, SGCDP, SGD, LGMD2F, Delta-SG

E.coli

Human

His-Tag

SDS-PAGE, Denatured

1 mg/mL (determined by Bradford assay)

> 85% by SDS-PAGE

28.1 kDa (257aa)

Delta-Sarcoglycan, Delta-sarcoglycan, 35DAG, CMD1L, DAGD, SG-delta, SGCDP, SGD, ATGP1980-10 µg, ATGP1980-20 µg, ATGP1980-50 µg, ATGP1980-100 µg, ATGP1980-250 µg, ATGP1980-500 µg, ATGP1980-1 mg, ATGP1980-10, ATGP1980-20, ATGP1980-50, ATGP1980-100, ATGP1980-250, ATGP1980-500, ATGP1980-1

Sylvius N, Duboscq-Bidot L, et al. (2003) . Am J Med Genet A. 120A (1) :8-12.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol

Cytoskeleton

NP_001121681

Q92629

Human

KVMNFT IDGMGNLRIT EKGLKLEGDS EFLQPLYAKE IQSRPGNALY FKSARNVTVN ILNDQTKVLT QLITGPKAVE AYGKKFEVKT VSGKLLFSAD NNEVVVGAER LRVLGAEGTV FPKSIETPNV RADPFKELRL ESPTRSLVME APKGVEINAE AGNMEATCRT ELRLESKDGE IKLDAAKIRL PRLPHGSYTP TGTRQKVFEI CVCANGRLFL SQAGAGSTCQ INTSVCL