Recombinant humaan DNAM-1/CD226 eiwit

CD226, also known as CD226 antigen isoform, is a member of the immunoglobulin superfamily containing 2 Ig-like domains of the V-set. It is an activating receptor expressed on NK cells and T cells and plays an important role in cytotoxicity of these cells against target cells. It mediates platelet and megakaryocytic cell adhesion to vascular endothelial cells. Recombinant human CD226, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

CD226 antigen isoform, CD226, DNAM-1, DNAM1, PTA1, TLiSA1

Baculovirus

Human

HIgG-His-Tag

SDS-PAGE

0.5 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 90% by SDS-PAGE

53.2 kDa (471aa)

DNAM1, CD226, CD226 antigen isoform, CD226, DNAM-1, DNAM1, PTA1, TLiSA1, ATGP3475-10 µg, ATGP3475-20 µg, ATGP3475-50 µg, ATGP3475-100 µg, ATGP3475-250 µg, ATGP3475-500 µg, ATGP3475-1 mg, ATGP3475-10, ATGP3475-20, ATGP3475-50, ATGP3475-100, ATGP3475-250, ATGP3475-500, ATGP3475-1

Vo AV., et al. (2016) Mol Immunol. 69:70-76.; ; Kojima H., et al. (2003) J Biol Chem. 278:36748-36753.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Immunology

NP_006557

Q15762

Human

Ala

ADPEEVLWHT SVPFAENMSL ECVYPSMGIL TQVEWFKIGT QQDSIAIFSP THGMVIRKPY AERVYFLNST MASNNMTLFF RNASEDDVGY YSCSLYTYPQ GTWQKVIQVV QSDSFEAAVP SNSHIVSEPG KNVTLTCQPQ MTWPVQAVRW EKIQPRQIDL LTYCNLVHGR NFTSKFPRQI VSNCSHGRWS VIVIPDVTVS DSGLYRCYLQ ASAGENETFV MRLTVAEGKT DNLEPKSCDK THTCPPCPAP ELLGGPSVFL FPPKPKDTLM ISRTPEVTCV VVDVSHEDPE VKFNWYVDGV EVHNAKTKPR EEQYNSTYRV VSVLTVLHQD WLNGKEYKCK VSNKALPAPI EKTISKAKGQ PREPQVYTLP PSRDELTKNQ VSLTCLVKGF YPSDIAVEWE SNGQPENNYK TTPPVLDSDG SFFLYSKLTV DKSRWQQGNV FSCSVMHEAL HNHYTQKSLS LSPGKHHHHH H