Recombinant humaan DR6/TNFRSF21-eiwit

TNFRSF21, also known as tumor necrosis factor receptor superfamily member 21, is a transmembrane protein in the TNF receptor superfamily. It promotes apoptosis through the activation of NF-kappa-B pathway. Binding of N-terminal APP (N-APP) and TNFRSF21 triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6) . This protein plays a role in signaling cascades triggered by stimulation of T-cell receptor. Recombinant human TNFRSF21 protein, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Tumor necrosis factor receptor superfamily member 21, TNFRSF21, BM-018, CD358, DR6, Death receptor 6

Baculovirus

Human

HIgG-His-Tag

SDS-PAGE

1 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 85% by SDS-PAGE

60.4 kDa (547aa)

DR6, TNFRSF21, Tumor necrosis factor receptor superfamily member 21, TNFRSF21, BM-018, CD358, DR6, ATGP3803-10 µg, ATGP3803-20 µg, ATGP3803-50 µg, ATGP3803-100 µg, ATGP3803-250 µg, ATGP3803-500 µg, ATGP3803-1 mg, ATGP3803-10, ATGP3803-20, ATGP3803-50, ATGP3803-100, ATGP3803-250, ATGP3803-500, ATGP3803-1

Wang Y., et al, (2015) J Mol Neurosci. 56:966-976.; ; Fujikura D., et al, (2017) Nat Commun. 8:13957.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol, 0.1mM PMSF.

Apoptosis

NP_055267

O75509

Human

Gln42