Recombinant humaan DUSP26 eiwit

DuSP26 inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. This protein inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. DuSP26 can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK) . Recombinant human DuSP26 protein, fused to His-tag at N-terminus, was expressed in E. coli.

Dual specificity protein phosphatase 26, Dual specificity phosphatase SKRP3, Low-molecular-mass dual-specificity phosphatase 4, DSP-4, LDP-4, Mitogen-activated protein kinase phosphatase 8, MAP kinase phosphatase 8, MKP-8, Novel amplified gene in thyroid anaplastic cancer, Neuroendocrine-associated phosphatase, DUSP24, LDP4, MKP8, NATA1, SKRP3, NEAP

E.coli

Human

His-Tag

SDS-PAGE, Denatured

0.25 mg/mL (determined by Bradford assay)

> 85% by SDS-PAGE

26.3 kDa (234aa)

DuSP26, Dual specificity protein phosphatase 26, Dual specificity protein phosphatase 26, Dual specificity phosphatase 26 (putative), DuSP24, LDP-4, MKP8, NATA1, SKRP3, ATGP2324-10 µg, ATGP2324-20 µg, ATGP2324-50 µg, ATGP2324-100 µg, ATGP2324-250 µg, ATGP2324-500 µg, ATGP2324-1 mg, ATGP2324-10, ATGP2324-20, ATGP2324-50, ATGP2324-100, ATGP2324-250, ATGP2324-500, ATGP2324-1

Vasudevan S.A.. et al. (2005) . Biochem. Biophys. Res. Commun. 330:511-518; ; Yu W., et al. (2007) . Oncogene 26:1178-1187;

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 0.4M urea

Signal Transduction

NP_076930

Q9BV47

Human

MGSSHHHHHH SSGLVPRGSH MGSMCPGNWL WASMTFMARF SRSSSRSPVR TRGTLEEMPT VQHPFLNVFE LERLLYTGKT ACNHADEVWP GLYLGDQDMA NNRRELRRLG ITHVLNASHS RWRGTPEAYE GLGIRYLGVE AHDSPAFDMS IHFQTAADFI HRALSQPGGK ILVHCAVGVS RSATLVLAYL MLYHHLTLVE AIKKVKDHRG IIPNRGFLRQ LLALDRRLRQ GLEA