Recombinant humaan E-Cadherine/CDH1-eiwit

CDH1, also known as cadherin-1, is a member of cell surface glycoproteins that meditate cell adhesion. Human CDH1 shares amino acid sequence identity with the rat and mouse proteins. It is a single-pass transmembrane protein that meditates calcium-dependent epithelial cell adhesion. This protein preferentially interacts with themselves in a homophilic manner in connecting cells. It may thus contribute to the sorting of heterogeneous cell types. It is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. It is a ligand for integrin alpha-E/beta-7. Recombinanat human CDH1, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

CDH1, Arc-1, CD324, CDHE, ECAD, LCAM, UVO, Cadherin-1, Epithelial cadherin, Uvomorulin, CAM 120/80

Baculovirus

Human

His-Tag

SDS-PAGE

0.5 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 90% by SDS-PAGE

76.8 kDa (695aa)

E-Cadherin, CDH1, Arc-1, CD324, CDHE, ECAD, LCAM, UVO, ATGP3307-10 µg, ATGP3307-20 µg, ATGP3307-50 µg, ATGP3307-100 µg, ATGP3307-250 µg, ATGP3307-500 µg, ATGP3307-1 mg, ATGP3307-10, ATGP3307-20, ATGP3307-50, ATGP3307-100, ATGP3307-250, ATGP3307-500, ATGP3307-1

Fulga V., et al. (2015) Anticancer Res. 35:759-765.; ; Zhang L., el al. (2014) Mutat. Res. 770:106-111.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Signal Transduction

NP_004351.1

P12830

Human

Glu24