Recombinant humaan EGFR-eiwit

EGFR, also known as epidermal growth factor receptor, is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinase. This protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-alpha, betacellulin, etc. It can also be recruited to form heterodimers with the ligand activated ErbB3 or ErbB4. EGFR signaling regulates multiple biological functions including cell proliferation, differentiation, motility, and apoptosis. It is overexpressed in a wide variety of tumors and is the target of several anti-cancer drugs. Recombinant human EGFR, fused to hIgG-His-tag at C-terminus, was expressed in CHO cell and purified by using conventional chromatography techniques.

Epidermal growth factor receptor, ERBB, ERBB1, HER1, NISBD2, PIG61, mENA, ERRP, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1, erythroblastic leukemia viral (v-erb-b) oncogene homolog (avian)

CHO Cell

Human

HIgG-His-Tag

SDS-PAGE

0.25 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 90% by SDS-PAGE

95.5 kDa (860aa)

EGFR, ATGP3335-10 µg, ATGP3335-20 µg, ATGP3335-50 µg, ATGP3335-100 µg, ATGP3335-250 µg, ATGP3335-500 µg, ATGP3335-1 mg, ATGP3335-10, ATGP3335-20, ATGP3335-50, ATGP3335-100, ATGP3335-250, ATGP3335-500, ATGP3335-1

Schlessinger J., et al. (200) Cell. 103:211-225.; ; Singh A.B., et al. (2005) Cell. Signal. 17:1183-1193.

Moon OJ, et al. An Optimally Fabricated Platform Guides Cancer-Specific Activation of Chemotherapeutic Drugs and Toxicity-Free Cancer Treatment. (Adv Healthc Mater. 2022) {https://pubmed.ncbi.nlm.nih.gov/35670274/}; ; Moon OJ, et al. Tumor-specific release of copper-incorporated diethyldithiocarbamate from an optimized apoferritin scaffold enables both potent and safe anti-cancer therapy. (Chemical Engineering Journal. 2023) {https://doi.org/10.1016/j.cej.2023.145176}

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Signal Transduction

NP_005219

P00533

Human

Leu25