Recombinant humaan ELP4-eiwit

ELP4 is a component of the six subunit elongator complex, a histone acetyltransferase complex that associates directly with RNA polymerase II during transcriptional elongation. The human gene can partially complement sensitivity phenotypes of yeast ELP4 deletion mutants. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined. Recombinant human ELP4 protein, fused to His-tag at N-terminus, was expressed in E. coli.

Elongator complex protein 4, C11orf19, dJ68P15A.1, PAX6NEB, PAXNEB

E.coli

Human

His-Tag

SDS-PAGE, Denatured

1 mg/mL (determined by Bradford assay)

> 80% by SDS-PAGE

49 kDa (447aa)

ELP4, Elongator complex protein 4, C11orf19, dJ68P15A.1, PAX6NEB, PAXNEB, ATGP2846-10 µg, ATGP2846-20 µg, ATGP2846-50 µg, ATGP2846-100 µg, ATGP2846-250 µg, ATGP2846-500 µg, ATGP2846-1 mg, ATGP2846-10, ATGP2846-20, ATGP2846-50, ATGP2846-100, ATGP2846-250, ATGP2846-500, ATGP2846-1

Strug, L.J., et al. (2009) Eur. J. Hum. Genet. 17 (9), 1171-1181.; ; Miele, A., et al. (2007) J. Cell. Biochem. 102 (1), 136-148.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol

Epigenomics (Transcription & Translation)

NP_061913

Q96EB1

Human

MGSSHHHHHH SSGLVPRGSH MGSMAAVATC GSVAASTGSA VATASKSNVT SFQRRGPRAS VTNDSGPRLV SIAGTRPSVR NGQLLVSTGL PALDQLLGGG LAVGTVLLIE EDKYNIYSPL LFKYFLAEGI VNGHTLLVAS AKEDPANILQ ELPAPLLDDK CKKEFDEDVY NHKTPESNIK MKIAWRYQLL PKMEIGPVSS SRFGHYYDAS KRMPQELIEA SNWHGFFLPE KISSTLKVEP CSLTPGYTKL LQFIQNIIYE EGFDGSNPQK KQRNILRIGI QNLGSPLWGD DICCAENGGN SHSLTKFLYV LRGLLRTSLS ACIITMPTHL IQNKAIIARV TTLSDVVVGL ESFIGSERET NPLYKDYHGL IHIRQIPRLN NLICDESDVK DLAFKLKRKL FTIERLHLPP DLSDTVSRSS KMDLAESAKR LGPGCGMMAG GKKHLDF