Recombinant humaan erytropoëtine R/EPOR-eiwit

EPOR, also known as Erythropoietin receptor, mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, it dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. So it may also activate the LYN tyrosine kinase. Recombinant human EPOR, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

EPO-R, EPOR, Erythropoietin receptor

Baculovirus

Human

His-Tag

SDS-PAGE

0.5 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 95% by SDS-PAGE

25.6 kDa (232aa)

Erythropoietin R, EPO-R, EPOR, ATGP3252-10 µg, ATGP3252-20 µg, ATGP3252-50 µg, ATGP3252-100 µg, ATGP3252-250 µg, ATGP3252-500 µg, ATGP3252-1 mg, ATGP3252-10, ATGP3252-20, ATGP3252-50, ATGP3252-100, ATGP3252-250, ATGP3252-500, ATGP3252-1

Nakamura Y., et al. (1992) Science. 257:1138-1141.; ; Kirito K., et al. (2002) Blood. 99:102-110.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Immunology

NP_000112

P19235

Human

APPPNLPDPK FESKAALLAA RGPEELLCFT ERLEDLVCFW EEAASAGVGP GNYSFSYQLE DEPWKLCRLH QAPTARGAVR FWCSLPTADT SSFVPLELRV TAASGAPRYH RVIHINEVVL LDAPVGLVAR LADESGHVVL RWLPPPETPM TSHIRYEVDV SAGNGAGSVQ RVEILEGRTE CVLSNLRGRT RYTFAVRARM AEPSFGGFWS AWSEPVSLLT PSDLDPHHHH HH