Recombinant humaan FAM49B-eiwit

FAM49B has been provisionally designated FAM49B pending further characterization. In a recent genome-wide transcriptional analysis, It identified a gene signature for multiple sclerosis (MS), which reverted back to normal during pregnancy. Reversion was particularly evident for 7 genes: SOCS2, TNFAIP3, NR4A2, CXCR4, POLR2J, FAM49B, and STAG3L1, most of which encode negative regulators of inflammation. Recombinant human FAM49B protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.

Protein FAM49B, Protein FAM49B, BM-009, L1

E.coli

Human

His-Tag

SDS-PAGE

1 mg/mL (determined by Bradford assay)

> 90% by SDS-PAGE

39.1 kDa (347aa) confirmed by MALDI-TOF

FAM49B, Protein FAM49B, Protein FAM49B, BM-009, L1, ATGP2033-10 µg, ATGP2033-20 µg, ATGP2033-50 µg, ATGP2033-100 µg, ATGP2033-250 µg, ATGP2033-500 µg, ATGP2033-1 mg, ATGP2033-10, ATGP2033-20, ATGP2033-50, ATGP2033-100, ATGP2033-250, ATGP2033-500, ATGP2033-1

Francesca Gilli. et al. (2011) Arch Neurol. 68:879-888; ; Niranjana A Nagarajan. et al. (2012) Nature Immunology. 13:579-586.;

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol 0.1M NaCl, 1mM DTT

Other

NP_057707

Q9NUQ9

Human

MGNLLKV LTCTDLEQGP NFFLDFENAQ PTESEKEIYN QVNVVLKDAE GILEDLQSYR GAGHEIREAI QHPADEKLQE KAWGAVVPLV GKLKKFYEFS QRLEAALRGL LGALTSTPYS PTQHLEREQA LAKQFAEILH FTLRFDELKM TNPAIQNDFS YYRRTLSRMR INNVPAEGEN EVNNELANRM SLFYAEATPM LKTLSDATTK FVSENKNLPI ENTTDCLSTM ASVCRVMLET PEYRSRFTNE ETVSFCLRVM VGVIILYDHV HPVGAFAKTS KIDMKGCIKV LKDQPPNSVE GLLNALRYTT KHLNDETTSK QIKSMLQ