Recombinant humaan FGB-eiwit

FGB also known as fibrinogen beta chain isoform 1 found in humans and most other vertebrates with a similar system of blood coagulation. FGB is the beta component of fibrinogen, a blood-borne glycoprotein composed of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency. Recombinant human FGB protein, fused to His-tag at N-terminus, was expressed in E. coli.

Fibrinogen beta chain isoform 1, HEL-S-78p

E.coli

Human

His-Tag

SDS-PAGE

1 mg/mL (determined by Bradford assay)

> 85% by SDS-PAGE

40kDa (351aa)

FGB, Fibrinogen beta chain isoform 1, HEL-S-78p, ATGP3094-10 µg, ATGP3094-20 µg, ATGP3094-50 µg, ATGP3094-100 µg, ATGP3094-250 µg, ATGP3094-500 µg, ATGP3094-1 mg, ATGP3094-10, ATGP3094-20, ATGP3094-50, ATGP3094-100, ATGP3094-250, ATGP3094-500, ATGP3094-1

Doolittle R.F., et al. (1984) Annu. Rev. Biochem. 53:195-229; ; Spraggon G., et al. (1997) Nature 389:455-462

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol

Cardiovascular

NP_005132

P02675

Human

DNENVVN EYSSELEKHQ LYIDETVNSN IPTNLRVLRS ILENLRSKIQ KLESDVSAQM EYCRTPCTVS CNIPVVSGKE CEEIIRKGGE TSEMYLIQPD SSVKPYRVYC DMNTENGGWT VIQNRQDGSV DFGRKWDPYK QGFGNVATNT DGKNYCGLPG EYWLGNDKIS QLTRMGPTEL LIEMEDWKGD KVKAHYGGFT VQNEANKYQI SVNKYRGTAG NALMDGASQL MGENRTMTIH NGMFFSTYDR DNDGWLTSDP RKQCSKEDGG GWWYNRCHAA NPNGRYYWGG QYTWDMAKHG TDDGVVWMNW KGSWYSMRKM SMKIRPFFPQ Q