Recombinant humaan FGF-19 (N-6His) eiwit

Molecular weight: 23.5 KDaDescription: Recombinant Human Fibroblast Growth Factor 19 is produced by our E.coli and the target gene encoding Phe27-Lys216 is expressed with a 6His tag at the N-terminus.Fibroblast growth factor 19 (FGF19) is a secreted protein which belongs to the FGFs family. FGF19 is expressed in fetal brain, cartilage, retina, and adult gall bladder. FGFs modulate cellular activity via at least 5 distinct subfamilies of high-affinity FGF receptors (FGFRs) : FGFR-1, -2, -3, and -4, all with intrinsic tyrosine kinase activity. FGFRs can be important for regulation of glucose and lipid homeostasis. FGF19 has important roles as a hormone produced in the ileum in response to bile acid absorption. It has been shown to cause resistance to diet-induced obesity and insulin desensitization and to improve insulin, glucose, and lipid profiles in diabetic rodents. FGF19 can be considered as a regulator of energy expenditure.

Fibroblast growth factor 19; FGF-19; FGF19

O95750

FGF-19

Lyophilized from a 0.2 ?m filtered solution of 20mM Tris-HCl, 150mM NaCl, 1mM EDTA, pH 8.0.

Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing) . Lyophilized proteins are shipped at ambient temperature.