Recombinant humaan FGF R2 bèta (lllb) eiwit

FGF R2 beta (lllb), also known as fibroblast growth factor receptor 2 isoform 9, is a member of the fibroblast growth factor receptor family. This protein has important roles in embryonic development and tissue repair, especially bone and blood vessels. Like the other members of the fibroblast growth factor receptor family, these receptors signal by binding to their ligand and dimerisation (pairing of receptors), which causes the tyrosine kinase domains to initiate a cascade of intracellular signals. On a molecular level these signals mediate cell division, growth and differentiation. Also, it is required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Mutations in FGF R2 beta are associated with numerous medical conditions that include abnormal bone development (e.g. craniosynostosis syndromes: Apert syndrome, Antley-Bixler syndrome, Pfeiffer syndrome, Crouzon syndrome, Jackson-Weiss syndrome) and cancer. (e.g. Breast cancer, endometrial cancer and melanoma) Recombinant Human FGF R2 beta (lllb), fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

FGF R2 beta, FGF R2b, BBDS, BEK, BFR-1, CD332, CEK3, CFD1, ECT1, JWS, K-SAM, KGFR, TK14, TK25, Fibroblast growth factor receptor 2, FGFR-2, K-sam , Keratinocyte growth factor receptor

Baculovirus

Human

HIgG-His-Tag

SDS-PAGE

0.5 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 95% by SDS-PAGE

56.8 kDa (507aa)

FGF R2 b (lllb), ATGP3899-10 µg, ATGP3899-20 µg, ATGP3899-50 µg, ATGP3899-100 µg, ATGP3899-250 µg, ATGP3899-500 µg, ATGP3899-1 mg, ATGP3899-10, ATGP3899-20, ATGP3899-50, ATGP3899-100, ATGP3899-250, ATGP3899-500, ATGP3899-1

Galzie Z., et al. (1997) Biochem. Cell Biol. 75:669-685.; ; Ornitz DM., et al, (1996) J Biol Chem. 271:15292-15297.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Growth factors

NP_001138391

P21802

Human

Arg22