Recombinant humaan FGF-receptor 1/FGFR1-eiwit

FGFR1, also known as fibroblast growth factor receptor 1, is a receptor tyrosine kinase whose ligands are specific members of the fibroblast growth factor family. It is involved in a multitude of physiological and pathological cellular processes, including cell growth, differentiation, angiogenesis, wound healing and tumorgenesis. The biological activities of the FGFs are mediated by a family of type I transmembrane tyrosine kinases which undergo dimerization and auto-phosphorylation after ligand binding. Recombinant human FGFR1 protein, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Fibroblast growth factor receptor 1 isoform 1, FGFR-1, Basic fibroblast growth factor receptor 1, BFGFR, bFGF-R-1, Fms-like tyrosine kinase 2, FLT-2, N-sam, Proto-oncogene c-Fgr, CD331, CEK, FGFBR, FLG, HBGFR, KAL2, Pfeiffer syndrome

Baculovirus

Human

His-Tag

SDS-PAGE

0.5 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 95% by SDS-PAGE

40.4 kDa (363aa)

FGF R1, Fibroblast growth factor receptor 1, FGFR1, bFGF-R-1, BFGFR, CD331, CEK, ECCL, FGFBR, FGFR-1, FLG, FLT-2, FLT2, HBGFR, HH2, HRTFDS, KAL2, N-SAM, OGD, ATGP3647-10 µg, ATGP3647-20 µg, ATGP3647-50 µg, ATGP3647-100 µg, ATGP3647-250 µg, ATGP3647-500 µg, ATGP3647-1 mg, ATGP3647-10, ATGP3647-20, ATGP3647-50, ATGP3647-100, ATGP3647-250, ATGP3647-500, ATGP3647-1

Bennett JT., et al, (2016) Am. J. Hum. Genet. 98: 579-587.; ; Wu AL., et al, (2013) PLoS One.8: e57322.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Cardiovascular

NP_075598

P11362

Human

Arg22