Recombinant humaan FGF-receptor 1/FGFR1-eiwit

FGFR1b, also known as fibroblast growth factor receptor 1 isoform 4, is a member members of the fibroblast growth factor family. It is required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Signaling of this protein is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation. Recombinant human FGFR1b protein, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Fibroblast growth factor receptor 1 isoform 1, FGFR-1, Basic fibroblast growth factor receptor 1, BFGFR, bFGF-R-1, Fms-like tyrosine kinase 2, FLT-2, N-sam, Proto-oncogene c-Fgr, CD331, CEK, FGFBR, FLG, HBGFR, KAL2, Pfeiffer syndrome

Baculovirus

Human

His-Tag

SDS-PAGE

0.25 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 90% by SDS-PAGE

30.4 kDa (272aa)

FGF R1 Kinase Domain, Fibroblast growth factor receptor 1 isoform 4, FGFR1b, FGFR1, bFGF-R-1, BFGFR, CD331, CEK, ECCL, FGFBR, FGFR-1, FLG, FLT-2, FLT2, HBGFR, HH2, HRTFDS, KAL2, N-SAM, OGD, ATGP3828-10 µg, ATGP3828-20 µg, ATGP3828-50 µg, ATGP3828-100 µg, ATGP3828-250 µg, ATGP3828-500 µg, ATGP3828-1 mg, ATGP3828-10, ATGP3828-20, ATGP3828-50, ATGP3828-100, ATGP3828-250, ATGP3828-500, ATGP3828-1

Lee JM., et al, (2008) Dev Biol. 314:341-350.; ; Xu R., et al, (2013) FEBS J. 280:2260-2270.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Cardiovascular

NP_075594

P11362

Human

Arg22

RPSPTLPEQD ALPSSEDDDD DDDSSSEEKE TDNTKPNPVA PYWTSPEKME KKLHAVPAAK TVKFKCPSSG TPNPTLRWLK NGKEFKPDHR IGGYKVRYAT WSIIMDSVVP SDKGNYTCIV ENEYGSINHT YQLDVVERSP HRPILQAGLP ANKTVALGSN VEFMCKVYSD PQPHIQWLKH IEVNGSKIGP DNLPYVQILK TAGVNTTDKE MEVLHLRNVS FEDAGEYTCL AGNSIGLSHH SAWLTVLEAL EERPAVMTSP LYLELEHHHH HH