Recombinant humaan FGF-receptor 4/FGFR4-eiwit

FGFR4, as known as fibroblast growth factor receptor 4 isoform 1, is a glycosylated transmembrane receptor tyrosine kinase. This protein is widely expressed during embryonic development and in adult liver, kidney, and lung. Also, it is associates with beta-Klotho and sulfated glycosaminoglycans, and these interactions increase the affinity of FGFR4 for its ligands as well as its signaling capacity. This receptor signaling is additionally required for skeletal muscle development in limbs. Recombinant human FGFR4, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Fibroblast growth factor receptor 4, FGFR-4, CD334, JTK2, TKF

Baculovirus

Human

His-Tag

SDS-PAGE

0.25 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 90% by SDS-PAGE

39.5 kDa (356aa)

FGF R4, Fibroblast growth factor receptor 4 isoform 1, FGFR4, CD334, JTK2, TKF, CD 334, CD334 antigen, fc13h 10, fc13h10, Fgfr 4, FGFR-4, Fgfr4, FGFR4_HUMAN, Fibroblast growth factor receptor 4, Hydroxyaryl protein kinase, JTK 2, JTK2, MGC20292, Protein tyrosine kinase, TKF, Tyrosine kinase related to fibroblast growth factor receptor, Tyrosylprotein kinase, ATGP3423-10 µg, ATGP3423-20 µg, ATGP3423-50 µg, ATGP3423-100 µg, ATGP3423-250 µg, ATGP3423-500 µg, ATGP3423-1 mg, ATGP3423-10, ATGP3423-20, ATGP3423-50, ATGP3423-100, ATGP3423-250, ATGP3423-500, ATGP3423-1

Liu R., et al. (2013) Cancer Res. 73:5926-5935.; ; Shen YY., et al. (2013) World J. Gastroenterol. 19:4568-4575.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Cardiovascular

NP_002002

P22455

Human

Leu22

LEASEEVELE PCLAPSLEQQ EQELTVALGQ PVRLCCGRAE RGGHWYKEGS RLAPAGRVRG WRGRLEIASF LPEDAGRYLC LARGSMIVLQ NLTLITGDSL TSSNDDEDPK SHRDPSNRHS YPQQAPYWTH PQRMEKKLHA VPAGNTVKFR CPAAGNPTPT IRWLKDGQAF HGENRIGGIR LRHQHWSLVM ESVVPSDRGT YTCLVENAVG SIRYNYLLDV LERSPHRPIL QAGLPANTTA VVGSDVELLC KVYSDAQPHI QWLKHIVING SSFGADGFPY VQVLKTADIN SSEVEVLYLR NVSAEDAGEY TCLAGNSIGL SYQSAWLTVL PEEDPTWTAA APEARYTDLE HHHHHH