Recombinant humaan FOLR1-eiwit

FOLR1 is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This protein is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene. Recombinant human FOLR1 protein, fused to His-tag at N-terminus, was expressed in E. coli.

Folate receptor alpha, FBP, FOLR

E.coli

Human

His-Tag

SDS-PAGE, Denatured

0.5 mg/mL (determined by Bradford assay)

> 85% by SDS-PAGE

27 kDa (233aa)

FOLR1, Folate receptor alpha, FBP, FOLR, ATGP2938-10 µg, ATGP2938-20 µg, ATGP2938-50 µg, ATGP2938-100 µg, ATGP2938-250 µg, ATGP2938-500 µg, ATGP2938-1 mg, ATGP2938-10, ATGP2938-20, ATGP2938-50, ATGP2938-100, ATGP2938-250, ATGP2938-500, ATGP2938-1

Lacey S.W., et al. (1989) J. Clin. Invest. 84:715-720.; ; Orr R.B., et al. (1994) Cancer Res. 54:3905-3911.;

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol

Cancer

NP_057936

P15328

Human

MGSSHHHHHH SSGLVPRGSH MGSRIAWART ELLNVCMNAK HHKEKPGPED KLHEQCRPWR KNACCSTNTS QEAHKDVSYL YRFNWNHCGE MAPACKRHFI QDTCLYECSP NLGPWIQQVD QSWRKERVLN VPLCKEDCEQ WWEDCRTSYT CKSNWHKGWN WTSGFNKCAV GAACQPFHFY FPTPTVLCNE IWTHSYKVSN YSRGSGRCIQ MWFDPAQGNP NEEVARFYAA AMS