Recombinant humaan FSBP-eiwit

Fibrinogen silencer-binding protein, also known as FSBP, is interacts with X11alpha. X11alpha/FSBP complex signals to the nucleus to repress glycogen synthase kinase-3beta promoter activity. X11alpha is a neuronal adaptor protein that interacts with the amyloid precursor protein (APP) through a centrally located phosphotyrosine binding domain to inhibit the production of Abeta peptide that is deposited in Alzheimer's disease brains. Recombinant human FSBP protein, fused to His-tag at N-terminus, was expressed in E. coli.

Fibrinogen silencer-binding protein, Fibrinogen silencer binding protein

E.coli

Human

His-Tag

SDS-PAGE, Denatured

0.25 mg/mL (determined by Bradford assay)

> 85% by SDS-PAGE

37.2 kDa (322aa)

FSBP, Fibrinogen silencer-binding protein, Fibrinogen silencer binding protein, ATGP2136-10 µg, ATGP2136-20 µg, ATGP2136-50 µg, ATGP2136-100 µg, ATGP2136-250 µg, ATGP2136-500 µg, ATGP2136-1 mg, ATGP2136-10, ATGP2136-20, ATGP2136-50, ATGP2136-100, ATGP2136-250, ATGP2136-500, ATGP2136-1

Lau KF., et al. (2010) Neuroreport. 21 (11) :761-6

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 1M urea, 10% glycerol

Cancer

NP_001243070

O95073

Human

MGSSHHHHHH SSGLVPRGSH MGSMVGKARS SNFTLSEKLD LLKLVKPYVK ILEEHTNKHS VIVEKNRCWD IIAVNYNAIG VDRPPRTAQG LRTLYKRLKE YAKQELLQQK ETQSDFKSNI SEPTKKVMEM IPQISSFCLV RDRNHIQSAN LDEEAQAGTS SLQVMLDHHP VAITVEVKQE EDIKPPPPLV LNSQQSDTLE QREEHELVHV MERSLSPSLS SVDMRMTSSP SSIPRRDDFF RHESGEHFRS LLGYDPQILQ MLKEEHQIIL ENQKNFGLYV QEKRDGLKRR QQLEEELLRA KIEVEKLKAI RLRHDLPEYN SL