Recombinant humaan Galectine-1/Lgals1-eiwit

Galectin-1 is a member of the beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. This protein is an autocrine negative growth factor that regulates cell proliferation. It controls cell survival by inducing apoptosis of activated T cells and immature thymocytes, thus Galectin-1 has immunosuppressive and anti-inflammatory properties. Galectin-1 also regulates tumor angiogenesis and is a target for angiostatic cancer therapy. Recombinant human Galectin-1 was expressed in E. coli and purified by using conventional chromatography

Gal-1, 14 kDa laminin-binding protein, HLBP14, 14 kDa lectin, Beta-galactoside-binding lectin L-14-I, Galaptin, HBL, HPL, Lactose-binding lectin 1, Lectin galactoside-binding soluble 1, Putative MAPK-activating protein PM12, S-Lac lectin 1, GBP

E.coli

Human

Non-Tagged

SDS-PAGE

1 mg/mL (determined by Bradford assay)

< 1 EU per 1ug of protein (determined by LAL method)

> 90% by SDS-PAGE

14.7 kDa (135aa) confirmed by MALDI-TOF

Galectin1, GAL1, GBP, LGALS1, S-Lac lectin1, galaptin, lactose-binding lectin 1, 14 kDa lectin, Beta galactoside binding lectin, Beta galactoside binding lectin L 14 I, DKFZp686E23103, Galectin, Galectin1, GBP, HBL, HPL, Lactose binding lectin 1, MAPK activating protein MP12, Lectin galactoside binding soluble 1, LGALS 1, Putative MAPK activating protein MP12, S Lac lectin 1., ATGP0385-10 µg, ATGP0385-20 µg, ATGP0385-50 µg, ATGP0385-100 µg, ATGP0385-250 µg, ATGP0385-500 µg, ATGP0385-1 mg, ATGP0385-10, ATGP0385-20, ATGP0385-50, ATGP0385-100, ATGP0385-250, ATGP0385-500, ATGP0385-1

Robert Kiss., et al. (2006) . Glycobiology. 6 (11) :137R-157R; ; Poirier F., et al. (2009) . Dev Growth Differ. 51 (7) :607-15.;

Suzuki O et al., Galectin-1-mediated cell adhesion, invasion and cell death in human anaplastic large cell lymphoma: Regulatory roles of cell surface glycans. (Int J Oncol. 2014) {https://pubmed.ncbi.nlm.nih.gov/24589677/}; ; Suzuki O et al., Sialylation and glycosylation modulate cell adhesion and invasion to extracellular matrix in human malignant lymphoma: Dependency on integrin and the Rho GTPase family. (Int J Oncol. 2015) {https://pubmed.ncbi.nlm.nih.gov/26497328/}; ; Campanero-Rhodes M.A et al., Exploration of Galectin Ligands Displayed on Gram-Negative Respiratory Bacterial Pathogens with Different Cell Surface Architectures. (Biomolecules. 2021) {https://pubmed.ncbi.nlm.nih.gov/33919637/}; ; Fabregat FN et al., Structure of the Lipopolysaccharide from Paenalcaligenes hominis: A Chemical Perspective on Immune Recognition. (JACS Au. 2025) {https://doi.org/10.1021/jacsau.5c00441}

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 7.5) containing 10% glycerol

Apoptosis

NP_002296.1

P09382

Human

MACGLVASNL NLKPGECLRV RGEVAPDAKS FVLNLGKDSN NLCLHFNPRF NAHGDANTIV CNSKDGGAWG TEQREAVFPF QPGSVAEVCI TFDQANLTVK LPDGYEFKFP NRLNLEAINY MAADGDFKIK CVAFD