Recombinant humaan GDF-15 eiwit

Growth differentiation factor 15 (GDF-15) is a protein belonging to the transforming growth factor beta superfamily that has a role in regulating inflammatory and apoptotic pathways in injured tissues and during disease processes. This protein is most abundant in the liver, with lower levels seen in some other tissues. Its expression in liver can be significantly up-regulated in during injury of organs such as liver, kidney, heart and lung. GDF-15 was expressed in E. coli and purifed by conventional chromatography, after refolding of the isolated inclusion bodies in a renaturation buffer.

Growth differentiation factor 15, GDF15, GDF-15, MIC-1, MIC1, NAG-1, PDF, PLAB, PTGFB, Growth differentiation factor 15 NSAID regulated protein 1, Placental TGF beta, GDF 15, Growth/differentiation factor 15, Macrophage inhibitory cytokine 1, MIC 1, NAG 1, NAG1, NRG 1, NRG1, NSAID, NSAID (nonsteroidal anti inflammatory drug) activated protein 1, Placental bone morphogenetic protein, Placental bone morphogenic protein, Prostate differentiation factor, PTGF beta, PTGFB.

E.coli

Human

His-Tag

SDS-PAGE

0.5 mg/mL (determined by Bradford assay)

< 1 EU per 1ug of protein (determined by LAL method)

> 95% by SDS-PAGE

16.7 kDa (151aa) confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)

GDF15, Growth differentiation factor 15, GDF15, GDF-15, MIC-1, MIC1, NAG-1, PDF, PLAB, PTGFB, Growth differentiation factor 15 NSAID regulated protein 1, Placental TGF beta, GDF 15, Growth/differentiation factor 15, Macrophage inhibitory cytokine 1, MIC 1, NAG 1, NAG1, NRG 1, NRG1, NSAID, NSAID (nonsteroidal anti inflammatory drug) activated protein 1, Placental bone morphogenetic protein, Placental bone morphogenic protein, Prostate differentiation factor, PTGF beta, PTGFB., ATGP0410-10 µg, ATGP0410-20 µg, ATGP0410-50 µg, ATGP0410-100 µg, ATGP0410-250 µg, ATGP0410-500 µg, ATGP0410-1 mg, ATGP0410-10, ATGP0410-20, ATGP0410-50, ATGP0410-100, ATGP0410-250, ATGP0410-500, ATGP0410-1

Paralkar V.M, et al. (1998) J Biol Chem. 273:13760-13767.; ; Hsiao E, Koniaris L., et al. (2000) Mol Cell Biol 20 (10) :3742-51. ;

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 10 mM Sodium Citrate buffer (pH 3.5) containing 10% glycerol

Growth factors

NP_004855

Q99988

Human

MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMARA RNGDHCPLGP GRCCRLHTVR ASLEDLGWAD WVLSPREVQV TMCIGACPSQ FRAANMHAQI KTSLHRLKPD TVPAPCCVPA SYNPMVLIQK TDTGVSLQTY DDLLAKDCHC I