Recombinant humaan GGPS1-eiwit

Geranylgeranyl pyrophosphate synthase isoform A, also known as GGPS1, is a member of the prenyltransferase family. Predominantly expressed in testis, heart and skeletal muscle, GGPS1 localizes to the cytoplasm and catalyzes the formation of geranylgeranyl pyrophosphate, a precursor of geranylgeranylated proteins and carotenoids. GGPS1 is an important molecule responsible for the C20-prenylation of proteins and for the regulation of a nuclear hormone receptor. Recombinant human GGPS1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Geranylgeranyl pyrophosphate synthase isoform A, Geranylgeranyl pyrophosphate synthase isoform A, GGPPS, GGPPS1, GGPP synthetase

E.coli

Human

His-Tag

SDS-PAGE

1 mg/mL (determined by Bradford assay)

> 90% by SDS-PAGE

37 kDa (320aa) confirmed by MALDI-TOF

GGPS1, Geranylgeranyl pyrophosphate synthase isoform A, Geranylgeranyl pyrophosphate synthase isoform A, GGPPS, GGPPS1, GGPP synthetase, ATGP0702-10 µg, ATGP0702-20 µg, ATGP0702-50 µg, ATGP0702-100 µg, ATGP0702-250 µg, ATGP0702-500 µg, ATGP0702-1 mg, ATGP0702-10, ATGP0702-20, ATGP0702-50, ATGP0702-100, ATGP0702-250, ATGP0702-500, ATGP0702-1

Okada K., et al. (2000) Plant Physiol. 122:1045-1056.; ; Kainou T., et al. (1999) Biochem Biophys. 1437:330-340.;

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% glycerol

Cancer

NP_001032354

O95749

Human

MEKTQETVQR ILLEPYKYLL QLPGKQVRTK LSQAFNHWLK VPEDKLQIII EVTEMLHNAS LLIDDIEDNS KLRRGFPVAH SIYGIPSVIN SANYVYFLGL EKVLTLDHPD AVKLFTRQLL ELHQGQGLDI YWRDNYTCPT EEEYKAMVLQ KTGGLFGLAV GLMQLFSDYK EDLKPLLNTL GLFFQIRDDY ANLHSKEYSE NKSFCEDLTE GKFSFPTIHA IWSRPESTQV QNILRQRTEN IDIKKYCVHY LEDVGSFEYT RNTLKELEAK AYKQIDARGG NPELVALVKH LSKMFKEENE