Recombinant humaan GITR Ligand/TNFSF18-eiwit

TNFSF18, also known as GITRL, belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF18/AITR/GITR. It is Important for interactions between activated T-lymphocytes and endothelial cells and may modulate T-lymphocyte survival in peripheral tissues. This cytokine is also found to be expressed in endothelial cells, and is thought to be important for interaction between T lymphocytes and endothelial cells. Recombinant human TNFSF18 protein was expressed in E. coli and purified by conventional chromatography, after refolding of the isolated inclusion bodies in a renaturation buffer.

Activation-inducible TNF-related ligand, AITRL, GITRL, Glucocorticoid-induced TNF-related ligand, hGITRL, TL6, TNF superfamily member 18, Tumor necrosis factor (ligand) superfamily member 18

E.coli

Human

Non-Tagged

SDS-PAGE

0.5 mg/mL (determined by Bradford assay)

> 90% by SDS-PAGE

14.6 kDa (129aa) confirmed by MALDI-TOF

GITR Ligand, TNFSF18, Tumor necrosis factor (ligand) superfamily member 18, AITRL, TL6, GITRL, hGITRL, ATGP1249-10 µg, ATGP1249-20 µg, ATGP1249-50 µg, ATGP1249-100 µg, ATGP1249-250 µg, ATGP1249-500 µg, ATGP1249-1 mg, ATGP1249-10, ATGP1249-20, ATGP1249-50, ATGP1249-100, ATGP1249-250, ATGP1249-500, ATGP1249-1

Kwon B, et al. (1999) J Biol Chem 274 (10) : 6056-61.; ; Gurney AL, et al. (1999) . Curr Biol 9 (4) : 215-8.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 10 mM Sodium Citrate buffer (pH 3.5) containing 1mM DTT, 10% glycerol

Hormones & Cytokines

NP_005083

Q9UNG2

Human

MQLETAKEPC MAKFGPLPSK WQMASSEPPC VNKVSDWKLE ILQNGLYLIY GQVAPNANYN DVAPFEVRLY KNKDMIQTLT NKSKIQNVGG TYELHVGDTI DLIFNSEHQV LKNNTYWGII LLANPQFIS