Recombinant humaan GITR/TNFRSF18-eiwit

TNFRSF18, also known as tumor necrosis factor receptor superfamily member 18 isoform 1, is receptor for TNFSF18. It seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. TNFRSF18 mediated NF-kappa-B activation via the TRAF2/NIK pathway. Also, this protein reciprocally stimulated and activate intracellular signals regulating immune functions. In particular, GITR-driven T-cell co-stimulation was found to be the main mechanism by which the GITRL-GITR system contributes to tumor rejection and the development of autoimmune/inflammatory diseases. Recombinant human TNFRSF18, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Tumor necrosis factor receptor superfamily member 18, Activation-inducible TNFR family receptor, Glucocorticoid-induced TNFR-related protein, CD357, AITR, GITR

Baculovirus

Human

HIgG-His-Tag

SDS-PAGE

0.5 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 95% by SDS-PAGE

41.6 kDa (376aa)

GITR, TNFRSF18, Tumor necrosis factor receptor superfamily member 18 isoform 1, AITR, CD357, GITR, GITR-D, ATGP3319-10 µg, ATGP3319-20 µg, ATGP3319-50 µg, ATGP3319-100 µg, ATGP3319-250 µg, ATGP3319-500 µg, ATGP3319-1 mg, ATGP3319-10, ATGP3319-20, ATGP3319-50, ATGP3319-100, ATGP3319-250, ATGP3319-500, ATGP3319-1

Lacal PM., et al. (2013) J. Pharmacol. Exp. Ther. 347:164-172.; ; Xufre C., et al. (2013) Int. Immunol. 25:563-574.; ; Shimizu J., et al. (2002) Nat. Immunol. 3:135-142.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Hormones & Cytokines

NP_004186.1

Q9Y5U5

Human

Gln26