Recombinant humaan GNAQ-eiwit

GNAQ is a guanine nucleotide-binding protein. GNAQ, an alpha subunit in the Gq class, couples a seven-transmembrane domain receptor to activation of phospolipase C-beta. Mutations at this locus have been associated with problems in platelet activation and aggregation. A related pseudogene exists on chromosome 2. Recombinant human GNAQ protein, fused to His-tag at N-terminus, was expressed in E. coli.

Guanine nucleotide-binding protein G (q) subunit alpha, CMC1, G-ALPHA-q, GAQ, SWS

E.coli

Human

His-Tag

SDS-PAGE, Denatured

0.5 mg/mL (determined by Bradford assay)

> 90% by SDS-PAGE

44.5 kDa (382aa)

GNAQ, Guanine nucleotide-binding protein G (q) subunit alpha, CMC1, G-ALPHA-q, GAQ, SWS, ATGP2798-10 µg, ATGP2798-20 µg, ATGP2798-50 µg, ATGP2798-100 µg, ATGP2798-250 µg, ATGP2798-500 µg, ATGP2798-1 mg, ATGP2798-10, ATGP2798-20, ATGP2798-50, ATGP2798-100, ATGP2798-250, ATGP2798-500, ATGP2798-1

Mudhar, H.S, et al. (2013) Br J Ophthalmol 97 (7), 924-928; ; Chishiki, K., et al. (2013) Biochem. Biophys. Res. Commun. 435 (3), 414-419

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M uREA, 10% glycerol

Cardiovascular

NP_002063

P50148

Human

MGSSHHHHHH SSGLVPRGSH MGSMTLESIM ACCLSEEAKE ARRINDEIER QLRRDKRDAR RELKLLLLGT GESGKSTFIK QMRIIHGSGY SDEDKRGFTK LVYQNIFTAM QAMIRAMDTL KIPYKYEHNK AHAQLVREVD VEKVSAFENP YVDAIKSLWN DPGIQECYDR RREYQLSDST KYYLNDLDRV ADPAYLPTQQ DVLRVRVPTT GIIEYPFDLQ SVIFRMVDVG GQRSERRKWI HCFENVTSIM FLVALSEYDQ VLVESDNENR MEESKALFRT IITYPWFQNS SVILFLNKKD LLEEKIMYSH LVDYFPEYDG PQRDAQAARE FILKMFVDLN PDSDKIIYSH FTCATDTENI RFVFAAVKDT ILQLNLKEYN LV