Recombinant humaan GOPC-eiwit

GOPC, also known as PIST, is a PDZ domain-containing Golgi protein. This protein functions as a homooligomer that interacts with a variety of proteins and plays a role in intracellular protein trafficking and degradation. Additionally, GOPC is thought to regulate ionic currents via membrane channel modification and may also play a role in autophagy. Chromosomal aberrations in the gene encoding GOPC are found in glioblastoma multiform (GBM), a common and aggressive form of brain tumor, suggesting a role for mutated PIST in carcinogenesis. Recombinant GOPC protein was expressed in E. coli and purified by using conventional chromatography techniques.

Golgi-associated PDZ and coiled-coil motif-containing protein, CAL, dJ94G16.2, FIG, GOPC1, PIST, Golgi-associated PDZ and coiled-coil motif-containing protein CFTR associated ligand, dJ94G16.2, FIG Fused in glioblastoma, Golgi associated PDZ and coiled coil motif containing, Golgi associated PDZ and coiled coil motif containing protein, GOPC 1, OTTHuMP00000040403, PDZ protein interacting specifically with TC 10, PDZ protein interacting specifically with TC10, PDZ/coiled coil domain binding partner for the rho family GTPase TC 10, PDZ/coiled coil domain binding partner for the rho family GTPase TC10, Protein interacting specifically with Tc 10, Protein interacting specifically with Tc10.

E.coli

Human

His-Tag

SDS-PAGE

1 mg/mL (determined by Bradford assay)

> 90% by SDS-PAGE

21.5 kDa (198aa) confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)

GOPC, Golgi-associated PDZ and coiled-coil motif-containing protein, CAL, dJ94G16.2, FIG, GOPC1, PIST, Golgi-associated PDZ and coiled-coil motif-containing protein CFTR associated ligand, dJ94G16.2, FIG Fused in glioblastoma, Golgi associated PDZ and coiled coil motif containing, Golgi associated PDZ and coiled coil motif containing protein, GOPC 1, OTTHuMP00000040403, PDZ protein interacting specifically with TC 10, PDZ protein interacting specifically with TC10, PDZ/coiled coil domain binding partner for the rho family GTPase TC 10, PDZ/coiled coil domain binding partner for the rho family GTPase TC10, Protein interacting specifically with Tc 10, Protein interacting specifically with Tc10., ATGP0485-10 µg, ATGP0485-20 µg, ATGP0485-50 µg, ATGP0485-100 µg, ATGP0485-250 µg, ATGP0485-500 µg, ATGP0485-1 mg, ATGP0485-10, ATGP0485-20, ATGP0485-50, ATGP0485-100, ATGP0485-250, ATGP0485-500, ATGP0485-1

Cheng J., et al. (2002) J Biol Chem. 277 (5) :3520-9. ; ; Yao R., et al. (2001) Biochem Biophys Res Commun. 286 (4) :771-8.;

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 1mM DTT

Adhesion & Movement

NP_001017408

Q9HD26

Human

MGSSHHHHHH SSGLVPRGSH MIRKVLLLKE DHEGLGISIT GGKEHGVPIL ISEIHPGQPA DRCGGLHVGD AILAVNGVNL RDTKHKEAVT ILSQQRGEIE FEVVYVAPEV DSDDENVEYE DESGHRYRLY LDELEGGGNP GASCKDTSGE IKVLQGFNKK AVTDTHENGD LGTASETPLD DGASKLDDLH TLYHKKSY