Recombinant humaan GP130/IL6ST-eiwit

IL6ST, also known as interleukin6 signal transducer, belongs to class 1 cytokine receptor family. Binding of IL-6 (IL-11) to either the membrane-anchored or soluble IL-6R (IL-11R) initiates the association of IL-6 R (IL-11 R) with IL6ST when then undergoes homo-dimerization and signal transduction. Recombinant human IL6ST, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Interleukin 6 cytokine family signal transducer, gp130, oncostatin M receptor, GP130, CD130, sGP130, membrane glycoprotein 130, Interleukin-6 receptor subunit beta, IL-6RB

Baculovirus

Human

His-Tag

SDS-PAGE

0.25 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 95% by SDS-PAGE

68.9 kDa (605aa)

IL6ST, IL6ST, CD130, CDw130, GP130, GP130-RAPS, IL6R-beta, ATGP3271-10 µg, ATGP3271-20 µg, ATGP3271-50 µg, ATGP3271-100 µg, ATGP3271-250 µg, ATGP3271-500 µg, ATGP3271-1 mg, ATGP3271-10, ATGP3271-20, ATGP3271-50, ATGP3271-100, ATGP3271-250, ATGP3271-500, ATGP3271-1

Narazaki M., et al. (1993) Blood 82:1120-1126.; ; Taga T. and T. Kishimoto (1997) Annu. Rev. Immunol. 15:797-819.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Apoptosis

AAI17405

Q17RA0

Human

ELLDPCGYIS PESPVVQLHS NFTAVCVLKE KCMDYFHVNA NYIVWKTNHF TIPKEQYTII NRTASSVTFT DIASLNIQLT CNILTFGQLE QNVYGITIIS GLPPEKPKNL SCIVNEGKKM RCEWDRGRET HLETNFTLKS EWATHKFADC KAKRDTPTSC TVDYSTVYFV NIEVWVEAEN ALGKVTSDHI NFDPVYKVKP NPPHNLSVIN SEELSSILKL TWTNPSIKSV IILKYNIQYR TKDASTWSQI PPEDTASTRS SFTVQDLKPF TEYVFRIRCM KEDGKGYWSD WSEEASGITY EDRPSKAPSF WYKIDPSHTQ GYRTVQLVWK TLPPFEANGK ILDYEVTLTR WKSHLQNYTV NATKLTVNLT NDRYVATLTV RNLVGKSDAA VLTIPACDFQ ATHPVMDLKA FPKDNMLWVE WTTPRESVKK YILEWCVLSD KAPCITDWQQ EDGTVHRTYL RGNLAESKCY LITVTPVYAD GPGSPESIKA YLKQAPPSKG PTVRTKKVGK NEAVLEWDQL PVDVQNGFIR NYTIFYRTII GNETAVNVDS SHTEYTLSSL TSDTLYMVRM AAYTDEGGKD GPEFTFTTPK FAQGEIELEH HHHHH