Recombinant humaan Granzyme B-eiwit

GZMB also known as granzyme B is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface nonself antigens, usually peptides or proteins resulting from infection by intracellular pathogens. Recombinant human GZMB, fused to His-tag at N-terminus, was expressed in E. coli.

Granzyme B, CCPI, CGL-1, CGL1, CSP-B, CSPB, CTLA1, CTSGL1, HLP, SECT

E.coli

Human

His-Tag

SDS-PAGE, Denatured

1 mg/mL (determined by Bradford assay)

> 85% by SDS-PAGE

27.8 kDa (248aa)

Granzyme B, Granzyme B, CCPI, CGL-1, CGL1, CSP-B, CSPB, CTLA1, CTSGL1, HLP, SECT, ATGP2978-10 µg, ATGP2978-20 µg, ATGP2978-50 µg, ATGP2978-100 µg, ATGP2978-250 µg, ATGP2978-500 µg, ATGP2978-1 mg, ATGP2978-10, ATGP2978-20, ATGP2978-50, ATGP2978-100, ATGP2978-250, ATGP2978-500, ATGP2978-1

Xu W., et al. (2014) Eur. J. Immunol. 44 (1), 275-284; ; Fritsch K., et al. (2013) Ann. Hematol. 92 (12), 1603-1609

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol

Apoptosis

NP_004122

P10144

Human

MGSSHHHHHH SSGLVPRGSH MIIGGHEAKP HSRPYMAYLM IWDQKSLKRC GGFLIQDDFV LTAAHCWGSS INVTLGAHNI KEQEPTQQFI PVKRPIPHPA YNPKNFSNDI MLLQLERKAK RTRAVQPLRL PSNKAQVKPG QTCSVAGWGQ TAPLGKHSHT LQEVKMTVQE DRKCESDLRH YYDSTIELCV GDPEIKKTSF KGDSGGPLVC NKVAQGIVSY GRNNGMPPRA CTKVSSFVHW IKKTMKRY